Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1T6ZN)

Drug Name
Pacritinib Drug Info
Synonyms JAK inhibitor (alone or in combination)s
Cross-matching ID
PubChem CID
46216796
ChEBI ID
CHEMBL2035187
CAS Number
CAS 937272-79-2
TTD Drug ID
D0PN8H

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Pentose phosphate pathway 1.97 2.92e-2 25/30 (83.33%) TKT;PFKP;FBP1;...
Alanine, aspartate and glutamate metabolism 1.90 2.92e-2 27/37 (72.97%) ASS1;ALDH5A1;ASRGL1;...
Lysosome 1.84 3.40e-2 115/128 (89.84%) LITAF;FUCA1;AP3S1;...
Chronic myeloid leukemia 1.83 2.55e-2 72/76 (94.74%) CRK;MYC;SMAD3;...
Fatty acid elongation 1.82 2.33e-2 19/27 (70.37%) HADH;PPT1;ELOVL2;...
Endocrine and other factor-regulated calcium reabsorpti... 1.75 4.13e-2 49/53 (92.45%) PRKCA;GNAS;ATP1A1;...
Long-term depression 1.75 3.54e-2 55/60 (91.67%) PRKCA;LYN;GNAS;...
Fatty acid degradation 1.75 3.46e-2 40/43 (93.02%) ALDH7A1;HADH;ACADVL;...
Glutamatergic synapse 1.74 3.40e-2 97/114 (85.09%) PRKCA;SLC1A3;GNAS;...
Peroxisome 1.73 3.50e-2 72/82 (87.8%) IDH1;PXMP2;SOD2;...
Spliceosome -1.86 1.94e-2 101/150 (67.33%) HSPA1L;LSM2;DHX15;...
Proteasome -2.02 5.53e-3 44/46 (95.65%) PSMD13;PSMA1;PSMB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H