Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM1TJ8F)

Drug Name
Diethylcarbamazine Drug Info
Synonyms
Bitirazine; Camin; Caracide; Carbamazine; Carbilazine; Caricide; Cypip; Decacide; Diaethylcarbamazinum; Diethylcarbamazinum; Dietilcarbamazina; Ethodryl; Luxuran; Notezine; Spatonin; Diethyl carbamazine; Ditrazine Base; Banocide (TN); Camin (TN); Carbilazine (TN); Caricide (TN); Cypip (TN); Diethylcarbamazine (INN); Diethylcarbamazine [INN:BAN]; Diethylcarbamazinum [INN-Latin]; Dietilcarbamazina [INN-Spanish]; Ethodryl (TN); FR-1031; Filaribits (TN); Forte (TN); Hetrazan (TN); Spatonin (TN); N,N-Diethyl-4-methyl-1-piperazinecarboxamide; N,N-diethyl-4-methylpiperazine-1-carboxamide; 1-Diethylcarbamyl-4-methylpiperazine; 84L
Therapeutic ClassAnthelmintics
Cross-matching ID
PubChem CID
3052
ChEBI ID
CHEMBL4527
CAS Number
CAS 90-89-1
TTD Drug ID
D06RCB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.05 9.31e-3 34/36 (94.44%) RFC5;RPA3;POLE2;...
Proximal tubule bicarbonate reclamation 2.01 4.65e-3 21/23 (91.3%) CA2;PCK1;ATP1A2;...
Parkinson disease 1.88 2.17e-2 176/249 (70.68%) GNAI1;DAXX;PRKACB;...
Cell cycle 1.83 3.02e-2 110/124 (88.71%) TFDP1;CCNE2;PLK1;...
Nitrogen metabolism 1.81 3.54e-2 16/17 (94.12%) CA2;CA4;GLUD2;...
Homologous recombination 1.80 3.10e-2 35/41 (85.37%) RBBP8;RPA3;NBN;...
Allograft rejection -1.74 3.76e-2 32/38 (84.21%) HLA-DOA;CD86;HLA-G;...
Th1 and Th2 cell differentiation -1.76 3.10e-2 80/92 (86.96%) MAF;FOS;PLCG1;...
Mitophagy -1.77 3.09e-2 56/68 (82.35%) FIS1;KRAS;RHOT2;...
Influenza A -1.79 2.76e-2 156/172 (90.7%) PIK3R3;RSAD2;TNFRSF1A;...
Phagosome -1.80 2.86e-2 118/152 (77.63%) HLA-DPA1;MARCO;CTSS;...
Lysosome -1.82 3.22e-2 115/128 (89.84%) LGMN;LAMP1;SGSH;...
Other glycan degradation -1.84 3.22e-2 13/18 (72.22%) MAN2B2;MAN2B1;HEXB;...
Graft-versus-host disease -1.86 2.51e-2 32/42 (76.19%) HLA-DRB1;HLA-DPA1;KLRD1;...
Autoimmune thyroid disease -1.88 3.76e-2 46/53 (86.79%) HLA-DOA;CD86;IFNA21;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H