General Information of Drug (ID: DM1ZFCS)

Drug Name
Cephaeline Drug Info
Synonyms
Cephaeline; Cephaelin; 483-17-0; 7',10,11-Trimethoxyemetan-6'-ol; UNII-QA971541A1; Desmethylemetine; QA971541A1; Dihydropsychotrine; Cepheline; GNF-Pf-307; (1R)-1-[[(2S,3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol; NSC32944; Cephaelinel; (-)-Cephaeline; EINECS 207-591-6; Prestwick2_000428; Prestwick3_000428; Prestwick1_000428; Prestwick0_000428; AC1L9CF2; BSPBio_000416; SCHEMBL181711; SPBio_002355; CHEMBL255708
Cross-matching ID
PubChem CID
442195
ChEBI ID
CHEMBL3533
CAS Number
CAS 483-17-0
VARIDT Drug ID
DR01645

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
TNF signaling pathway 2.26 0.00e+0 103/112 (91.96%) NFKBIA;JUN;TNFAIP3;...
NF-kappa B signaling pathway 2.19 0.00e+0 90/104 (86.54%) RELB;GADD45B;NFKBIA;...
IL-17 signaling pathway 2.09 0.00e+0 84/94 (89.36%) NFKBIA;JUN;TNFAIP3;...
RIG-I-like receptor signaling pathway 1.89 5.74e-3 64/70 (91.43%) NFKBIA;IKBKE;CXCL8;...
Circadian rhythm 1.86 1.07e-2 26/31 (83.87%) PER2;PER1;BHLHE41;...
Cytosolic DNA-sensing pathway 1.86 8.93e-3 52/63 (82.54%) NFKBIA;IKBKE;IL6;...
Epstein-Barr virus infection 1.82 1.09e-2 189/202 (93.56%) RELB;GADD45B;NFKBIA;...
NOD-like receptor signaling pathway 1.73 3.25e-2 145/181 (80.11%) NFKBIA;JUN;TNFAIP3;...
C-type lectin receptor signaling pathway 1.73 2.89e-2 93/104 (89.42%) RELB;NFKBIA;JUN;...
AGE-RAGE signaling pathway in diabetic complications 1.71 3.06e-2 97/100 (97%) EGR1;JUN;CCL2;...
Ubiquitin mediated proteolysis 1.68 4.04e-2 87/140 (62.14%) DDB2;BIRC3;RCHY1;...
Basal transcription factors 1.67 3.89e-2 37/45 (82.22%) TAF2;CDK7;GTF2B;...
Transcriptional misregulation in cancer 1.67 3.59e-2 158/192 (82.29%) GADD45B;GADD45A;CXCL8;...
Osteoclast differentiation 1.67 3.44e-2 117/127 (92.13%) RELB;NFKBIA;JUN;...
Cell cycle 1.66 3.47e-2 110/124 (88.71%) GADD45B;GADD45A;WEE1;...
Inflammatory bowel disease 1.65 3.44e-2 58/65 (89.23%) JUN;IL6;NFKB1;...
Small cell lung cancer 1.64 3.51e-2 90/92 (97.83%) GADD45B;NFKBIA;GADD45A;...
Rheumatoid arthritis 1.61 4.46e-2 78/93 (83.87%) JUN;CCL2;FOS;...
Spliceosome 1.60 4.71e-2 101/150 (67.33%) SNW1;TCERG1;PRPF3;...
Influenza A 1.60 4.63e-2 156/172 (90.7%) NFKBIA;CCL2;IKBKE;...
GABAergic synapse -1.63 3.27e-2 76/89 (85.39%) GNG5;GNG7;SLC38A2;...
Pentose and glucuronate interconversions -1.66 2.53e-2 17/34 (50%) AKR1B10;UGT2B4;UGT2B15;...
Metabolism of xenobiotics by cytochrome P450 -1.67 2.53e-2 49/77 (63.64%) ADH6;SULT2A1;CYP3A4;...
N-Glycan biosynthesis -1.67 2.58e-2 38/50 (76%) MAN1C1;MOGS;B4GALT1;...
Central carbon metabolism in cancer -1.68 2.44e-2 67/70 (95.71%) AKT1;PDK1;SIRT3;...
Regulation of actin cytoskeleton -1.69 2.34e-2 185/218 (84.86%) FGF7;RDX;FGF20;...
Protein export -1.69 2.44e-2 17/23 (73.91%) SEC61B;SRP9;SRPRA;...
Melanogenesis -1.70 2.28e-2 74/101 (73.27%) DVL3;FZD10;CAMK2G;...
Various types of N-glycan biosynthesis -1.71 2.11e-2 26/39 (66.67%) ALG3;MGAT4B;MGAT1;...
Proximal tubule bicarbonate reclamation -1.73 1.80e-2 21/23 (91.3%) GLS2;SLC25A10;ATP1A1;...
Pentose phosphate pathway -1.73 1.89e-2 25/30 (83.33%) TALDO1;GPI;PRPS2;...
Glycosphingolipid biosynthesis -1.75 1.67e-2 37/57 (64.91%) B3GALT2;A4GALT;B3GNT2;...
Bacterial invasion of epithelial cells -1.76 1.22e-2 59/77 (76.62%) ARPC3;CTNNB1;PIK3R1;...
Glycine, serine and threonine metabolism -1.77 1.08e-2 31/40 (77.5%) CTH;GLDC;SHMT2;...
Gastric acid secretion -1.78 1.14e-2 63/76 (82.89%) ADCY2;KCNK2;PLCB3;...
Fc gamma R-mediated phagocytosis -1.78 1.06e-2 79/97 (81.44%) CRK;PLD2;AKT2;...
Nitrogen metabolism -1.79 9.59e-3 16/17 (94.12%) GLUD1;CA2;CA12;...
Biosynthesis of unsaturated fatty acids -1.81 8.45e-3 21/27 (77.78%) ELOVL2;ELOVL6;ELOVL1;...
Pyruvate metabolism -1.82 9.16e-3 41/47 (87.23%) ACAT1;MDH2;PCK2;...
Antigen processing and presentation -1.83 7.77e-3 60/78 (76.92%) CIITA;KLRC3;RFXAP;...
Glutathione metabolism -1.85 7.33e-3 43/57 (75.44%) SRM;RRM2;GSTA1;...
Bile secretion -1.86 8.14e-3 68/90 (75.56%) ATP1B2;SLC4A4;UGT2B4;...
Folate biosynthesis -1.98 1.53e-3 23/26 (88.46%) TPH1;AKR1B10;SPR;...
Starch and sucrose metabolism -2.02 0.00e+0 25/36 (69.44%) ENPP1;HK1;GYG2;...
Cysteine and methionine metabolism -2.02 0.00e+0 43/50 (86%) MAT1A;DNMT3A;GOT2;...
Ferroptosis -2.03 0.00e+0 36/41 (87.8%) SLC39A14;PCBP2;ACSL4;...
Glycolysis / Gluconeogenesis -2.13 0.00e+0 56/67 (83.58%) ALDH7A1;HK1;ADH7;...
Lysosome -2.14 0.00e+0 115/128 (89.84%) SLC11A2;CLN3;CTSF;...
Steroid biosynthesis -2.18 0.00e+0 19/20 (95%) CYP51A1;DHCR24;LSS;...
Protein processing in endoplasmic reticulum -2.26 0.00e+0 127/171 (74.27%) DNAJC1;HYOU1;BAG2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H