Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM201Q7)

Drug Name
SB 239063 Drug Info
Synonyms
SB 239063; 193551-21-2; SB239063; SB-239063; UNII-HII3DC8CPI; HII3DC8CPI; CHEMBL97162; trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole; CHEBI:90681; TRANS-1-(4-HYDROXYCYCLOHEXYL)-4-(4-FLUOROPHENYL)-5-(2-METHOXYPYRIMIDIN-4-YL) IMIDAZOLE; trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol; 4-[4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)imidazol-1-yl]cyclohexan-1-ol
Therapeutic ClassAnalgesics
Cross-matching ID
PubChem CID
5166
ChEBI ID
CHEMBL256835
CAS Number
CAS 193551-21-2
TTD Drug ID
D08LYB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.55 0.00e+0 34/36 (94.44%) POLE2;RFC2;RNASEH2A;...
Homologous recombination 2.28 0.00e+0 35/41 (85.37%) BRCA1;RAD51;RPA3;...
Mismatch repair 2.24 0.00e+0 22/23 (95.65%) RFC2;LIG1;RPA3;...
Fanconi anemia pathway 2.15 0.00e+0 36/54 (66.67%) BRCA1;RAD51;FANCI;...
Nucleotide excision repair 2.09 0.00e+0 40/47 (85.11%) POLE2;RFC2;LIG1;...
Pyrimidine metabolism 2.05 2.79e-3 40/56 (71.43%) TYMS;DCK;DPYD;...
Purine metabolism 1.85 9.58e-3 102/129 (79.07%) AK4;HPRT1;DCK;...
Cell cycle 1.84 8.38e-3 110/124 (88.71%) CDK1;CDC7;CDC45;...
Legionellosis -1.63 4.47e-2 51/57 (89.47%) C3;CASP9;IL12B;...
Staphylococcus aureus infection -1.63 4.50e-2 72/95 (75.79%) CAMP;DEFA4;KRT24;...
Intestinal immune network for IgA production -1.63 4.78e-2 38/48 (79.17%) IL2;HLA-DPA1;IL15RA;...
Mitophagy -1.64 4.76e-2 56/68 (82.35%) USP8;CSNK2A2;NBR1;...
Cytokine-cytokine receptor interaction -1.65 4.83e-2 246/295 (83.39%) AMHR2;ACKR4;OSMR;...
Autoimmune thyroid disease -1.68 3.63e-2 46/53 (86.79%) IL2;HLA-DPA1;TSHB;...
Various types of N-glycan biosynthesis -1.70 3.40e-2 26/39 (66.67%) MGAT4B;MAN1A1;DAD1;...
Antigen processing and presentation -1.71 2.90e-2 60/78 (76.92%) HSP90AA1;NFYC;HLA-F;...
Protein export -1.72 3.06e-2 17/23 (73.91%) SEC61A1;SEC11A;OXA1L;...
Allograft rejection -1.76 2.55e-2 32/38 (84.21%) FASLG;HLA-DOA;HLA-F;...
ABC transporters -1.83 1.28e-2 37/45 (82.22%) ABCB6;ABCC10;ABCC8;...
Asthma -1.84 1.28e-2 25/31 (80.65%) HLA-DPA1;CCL11;IL3;...
IL-17 signaling pathway -1.85 8.50e-3 84/94 (89.36%) CHUK;ANAPC5;CXCL3;...
Collecting duct acid secretion -1.93 2.55e-3 22/27 (81.48%) ATP6V0D1;ATP6V1D;ATP4B;...
Protein processing in endoplasmic reticulum -1.97 0.00e+0 127/171 (74.27%) YOD1;PRKCSH;CANX;...
Steroid hormone biosynthesis -2.00 0.00e+0 43/61 (70.49%) CYP1A1;HSD3B1;UGT2B15;...
Ferroptosis -2.07 0.00e+0 36/41 (87.8%) STEAP3;FTL;TFRC;...
Rheumatoid arthritis -2.24 0.00e+0 78/93 (83.87%) ATP6V1H;ATP6V0C;IL17A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.08uM - 10uM 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H