Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM21WBH)

Drug Name
MK-2461 Drug Info
Synonyms MK 2461
Cross-matching ID
PubChem CID
44137946
ChEBI ID
CHEMBL1822792
CAS Number
CAS 917879-39-1
TTD Drug ID
D00DRL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.17 0.00e+0 34/36 (94.44%) PCNA;POLE3;FEN1;...
One carbon pool by folate 1.99 8.85e-3 15/20 (75%) SHMT2;MTHFD2;TYMS;...
Glutathione metabolism 1.87 1.57e-2 43/57 (75.44%) CHAC1;PGD;SMS;...
Nucleotide excision repair 1.87 1.18e-2 40/47 (85.11%) PCNA;POLE3;RAD23B;...
Pantothenate and CoA biosynthesis 1.83 2.01e-2 14/21 (66.67%) DPYS;DPYD;ALDH3A2;...
Cysteine and methionine metabolism 1.71 4.13e-2 43/50 (86%) PHGDH;PSAT1;SMS;...
Drug metabolism 1.70 3.79e-2 78/151 (51.66%) ALDH3A1;DPYS;ADH5;...
Metabolism of xenobiotics by cytochrome P450 1.70 3.39e-2 49/77 (63.64%) AKR7A2;ALDH3A1;AKR7A3;...
Glycine, serine and threonine metabolism 1.66 4.85e-2 31/40 (77.5%) SHMT2;PHGDH;PSAT1;...
IL-17 signaling pathway -1.74 4.52e-2 84/94 (89.36%) ANAPC5;TNFAIP3;TRADD;...
Kaposi sarcoma-associated herpesvirus infection -1.77 3.41e-2 172/193 (89.12%) MICA;SRC;NFATC1;...
VEGF signaling pathway -1.79 3.47e-2 50/59 (84.75%) PIK3CB;CASP9;CDC42;...
FoxO signaling pathway -1.79 3.91e-2 118/131 (90.08%) TGFBR2;ATG12;G6PC3;...
Mineral absorption -1.81 3.45e-2 48/60 (80%) SLC26A6;SLC39A4;ATP1A2;...
Amoebiasis -1.87 2.61e-2 99/102 (97.06%) CD1A;IL1R2;LAMA4;...
Viral protein interaction with cytokine and cytokine re... -1.88 3.13e-2 84/100 (84%) IL20RA;TNFRSF10C;CCL22;...
Rheumatoid arthritis -1.88 3.55e-2 78/93 (83.87%) IL23A;TNFRSF11A;ITGB2;...
Chemokine signaling pathway -1.90 2.37e-2 163/192 (84.9%) ARRB1;SRC;CCL22;...
Epithelial cell signaling in Helicobacter pylori infect... -1.92 2.84e-2 62/70 (88.57%) PLCG2;F11R;ATP6AP1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H