Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2348V)

• Drug Name: PP-242 Drug Info
• Synonyms: PP242; TORKinib
• Cross-matching ID:
  PubChem CID: 135565635
  ChEBI ID: CHEMBL1241674
  CAS Number: CAS 1092351-67-1
  TTD Drug ID: D0H2CM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Other glycan degradation	1.97	1.41e-2	13/18 (72.22%)	GLB1;ENGASE;MAN2B2;...
Ribosome	1.81	3.16e-2	113/158 (71.52%)	RPS5;RPL13;RPL3;...
Fructose and mannose metabolism	-1.75	4.59e-2	30/33 (90.91%)	ALDOA;ALDOB;PMM2;...
Steroid hormone biosynthesis	-1.78	2.80e-2	43/61 (70.49%)	HSD11B1;CYP3A4;SULT2B1;...
Vitamin digestion and absorption	-1.88	4.08e-3	17/24 (70.83%)	SCARB1;SLC19A3;SLC5A6;...
PPAR signaling pathway	-1.91	4.90e-3	66/74 (89.19%)	HMGCS2;FABP4;SORBS1;...
Proteasome	-1.95	3.06e-3	44/46 (95.65%)	PSMC2;PSMB3;PSMA6;...
Glutathione metabolism	-1.99	0.00e+0	43/57 (75.44%)	GSTO1;GGCT;GCLC;...
Fat digestion and absorption	-2.03	0.00e+0	35/43 (81.4%)	DGAT1;GOT2;LIPF;...
Folate biosynthesis	-2.06	0.00e+0	23/26 (88.46%)	SPR;MOCS2;CBR1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
VCaP	CVCL_2235	Homo sapiens	0.37uM - 10uM	6H, 24H	Hide ▲