Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM23HCX)

• Drug Name: Dextropropoxyphene Drug Info
• Synonyms: Algafan; Antalvic; Destropropossifene; Dextropropoxifeno; Dextropropoxyphen; Dextropropoxyphenum; Dextroproxifeno; Femadol; Levopropoxyphene; Propoxyphene; Proxagesic; Proxyphen; Destropropossifene [DCIT]; Dextroproxifeno [Spanish]; SK 65; D-Propoxyphene; Dextropropoxifeno [INN-Spanish]; Dextropropoxyphene[INN:BAN]; Dextropropoxyphenum [INN-Latin]; Bulk dextropropoxyphene (non-dosage forms); Alpha-4-Dimethylamino-1,2-diphenyl-3-methyl-2-butanol propionate; Alpha-D-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol propionate; Alpha-D-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol-propionat; Alpha-D-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol-propionat [German]; Alpha-(+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-butanol propionate ester; Alpha-(+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-propionoxybutane; [(2S,3R)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate; (+)-1,2-Diphenyl-2-propionoxy-3-methyl-4-dimethylaminobutane; (+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-propionyloxybutane; (1S,2R)-1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propanoate; (D)-PROPOXYPHENE; (S)-alpha-(2-(Dimethylamino)-1-methylethyl)-alpha-phenylbenzeneethanol propanoate; 4-Dimethylamino-3-methyl-1,2-diphenyl-2-propoxybutane
• Therapeutic Class: Analgesics
• Cross-matching ID:
  PubChem CID: 10100
  ChEBI ID: CHEMBL51173
  CAS Number: CAS 469-62-5
  TTD Drug ID: D0D4PB
  INTEDE Drug ID: DR0478
  ACDINA Drug ID: D00564

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Pentose and glucuronate interconversions	2.07	0.00e+0	17/34 (50%)	AKR1B10;UGT2A3;UGT2B28;...
Drug metabolism	1.92	1.42e-2	78/151 (51.66%)	UGT2A3;ALDH3A1;UGT2B28;...
Retinol metabolism	1.91	9.49e-3	41/68 (60.29%)	CYP26B1;UGT2A3;UGT2B28;...
Mineral absorption	1.90	8.90e-3	48/60 (80%)	MT1X;MT1E;MT1H;...
PPAR signaling pathway	1.78	3.27e-2	66/74 (89.19%)	PLIN1;FABP7;PLIN2;...
Metabolism of xenobiotics by cytochrome P450	1.78	2.85e-2	49/77 (63.64%)	HSD11B1;CBR3;UGT2A3;...
Proximal tubule bicarbonate reclamation	1.78	2.54e-2	21/23 (91.3%)	AQP1;FXYD2;PCK1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲