Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM24XYQ)

• Drug Name: Bromperidol Drug Info
• Synonyms: bromperidol; 10457-90-6; Impromen; Bromoperidol; Tesoprel; Azurene; 4-(4-(4-bromophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one; UNII-LYH6F7I22E; Bromperidolum [INN-Latin]; R 11333; EINECS 233-943-3; 4-(4-(4-Bromophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone; CC 2489; BRN 1552256; LYH6F7I22E; 4-(4-(p-Bromophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone; RKLNONIVDFXQRX-UHFFFAOYSA-N; 4-(4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone; NCGC00016692-01; CAS-10457-90-6
• Cross-matching ID:
  PubChem CID: 2448
  ChEBI ID: CHEMBL31305
  CAS Number: CAS 10457-90-6
  TTD Drug ID: D00SHQ
  INTEDE Drug ID: DR0236

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ribosome biogenesis in eukaryotes	1.98	4.32e-3	52/108 (48.15%)	RPP38;NVL;GTPBP4;...
Aminoacyl-tRNA biosynthesis	1.91	4.32e-3	15/66 (22.73%)	NARS2;IARS2;DARS2;...
Arginine and proline metabolism	-1.79	3.56e-2	39/50 (78%)	ARG2;DAO;ALDH9A1;...
Amphetamine addiction	-1.81	2.60e-2	57/69 (82.61%)	TH;ARC;MAOB;...
Aldosterone synthesis and secretion	-1.81	3.12e-2	85/98 (86.73%)	ATP1B3;ITPR1;NPR1;...
Insulin secretion	-1.82	3.89e-2	75/86 (87.21%)	RIMS2;PRKACB;ADCY9;...
Synaptic vesicle cycle	-1.87	2.08e-2	63/78 (80.77%)	ATP6V1F;SLC6A9;SNAP25;...
Vibrio cholerae infection	-1.87	3.12e-2	44/50 (88%)	ADCY3;KCNQ1;PLCG2;...
Mineral absorption	-2.01	1.56e-2	48/60 (80%)	ATP2B2;SLC11A2;SLC31A1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲