Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM25FL8)

• Drug Name: Methimazole Drug Info
• Synonyms: methimazole; 60-56-0; thiamazole; Tapazole; 2-Mercapto-1-methylimidazole; Mercazolyl; 1-Methylimidazole-2-thiol; Thymidazole; Mercazole; Methimazol; Thymidazol; Thiamazol; Metazolo; Thycapzol; Metothyrine; Metothyrin; Merkazolil; Mercaptazole; Strumazol; Favistan; Basolan; Thycapsol; Metotirin; Danantizol; Thacapzol; Merkastan; Frentirox; Metizol; Tiamazol; Mercasolyl; 1-Methyl-1H-imidazole-2-thiol; Methylmercaptoimidazole; 1-Methyl-2-mercaptoimidazole; Methiamazole; Usaf el-30; Methimazolum; Mercazolylum; Tapuzole; Metimazol; Thimazole; Basolan; MMZ; Mercazol; Methamazole; Methizol; Methymazol; Metisol; Strumazole; Thiamazole; Thiamazolum; Thimazol; Thyrozol; Tiamazolo; Tirodril; EliLilly Brand of Methimazole; Estedi Brand of Methimazole; Henning Berlin Brand of Methimazole; Hexal Brand of Methimazole; Jones Brand of Methimazole; Merck Brand of Methimazole; Nourypharma Brand of Methimazole; Philopharm Brand of Methimazole; Sanofi Synthelabo Brand of Methimazole; Temmler Brand of Methimazole; Thiamazol Henning; Thiamazol Hexal; Tiamazolo [DCIT]; M0868; Henning, Thiamazol; Hexal, Thiamazol; Methimazole (USP); Methimazole [USAN:BAN]; Tapazole (TN); Thiamazol [INN-French]; Thiamazolum [INN-Latin]; Tiamazol [INN-Spanish]; Mestinon, Regonol, Pyridostigmine Bromide;Thiamazole (JP15/INN); N-Methyl-2-mercaptoimidazole; 1 Methyl 2 mercaptoimidazole; 1,3-Dihydro-1-Methyl-2H-Imidazol-2-Thione; 1,3-Dihydro-1-methyl-2H-imidazole-2-thione; 1-METHYL-1,3-DIHYDRO-2H-IMIDAZOLE-2-THIONE; 1-Methyl-1,3-dihydroimidazole-2-thione; 1-Methyl-2-Imidazolethione; 1-Methyl-2-imidazolethiol; 1-Methyl-imidazole-2-thiol; 1-Methylimidazole-2(3H)-thione; 1-Metylo 2 merkaptoimidazolem; 1-Metylo 2 merkaptoimidazolem [Polish]; 2-Mercaptomethylimidazole; 3-methyl-1H-imidazole-2-thione
• Therapeutic Class: Antithyroid Agents
• Cross-matching ID:
  PubChem CID: 1349907
  ChEBI ID: CHEMBL1515
  CAS Number: CAS 60-56-0
  TTD Drug ID: D0S4BR
  VARIDT Drug ID: DR00667
  ACDINA Drug ID: D00410

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Thiamine metabolism	-1.62	4.86e-2	12/15 (80%)	TPK1;AK1;NFS1;...
Rheumatoid arthritis	-1.67	2.90e-2	78/93 (83.87%)	ATP6V1F;IFNG;IL15;...
Ovarian steroidogenesis	-1.67	2.86e-2	41/51 (80.39%)	CYP17A1;STAR;HSD3B2;...
Proximal tubule bicarbonate reclamation	-1.68	2.76e-2	21/23 (91.3%)	ATP1B2;ATP1A2;PCK2;...
Drug metabolism	-1.69	2.76e-2	78/151 (51.66%)	CYP1A2;CYP2C19;UGT2A3;...
Retinol metabolism	-1.70	2.87e-2	41/68 (60.29%)	ADH1A;RETSAT;CYP1A2;...
Linoleic acid metabolism	-1.71	2.70e-2	21/29 (72.41%)	PLA2G2F;PLA2G4A;PLA2G2D;...
Ferroptosis	-1.71	2.81e-2	36/41 (87.8%)	VDAC2;TP53;GSS;...
Folate biosynthesis	-1.74	2.41e-2	23/26 (88.46%)	AKR1B1;AKR1B10;ALPL;...
Malaria	-1.78	1.73e-2	44/50 (88%)	IFNG;SELP;TGFB2;...
Legionellosis	-1.80	1.64e-2	51/57 (89.47%)	CASP1;NFKBIA;HSPA6;...
Sulfur relay system	-1.80	1.79e-2	5/8 (62.5%)	MPST;NFS1;TST
Cytokine-cytokine receptor interaction	-1.85	1.03e-2	246/295 (83.39%)	IL2RA;IL7;IL11;...
Steroid hormone biosynthesis	-1.88	5.21e-3	43/61 (70.49%)	CYP1A2;HSD3B2;UGT2A3;...
Glyoxylate and dicarboxylate metabolism	-1.91	1.17e-3	23/30 (76.67%)	GRHPR;MDH2;GLUL;...
Sulfur metabolism	-1.93	1.34e-3	9/10 (90%)	MPST;SQOR;ETHE1;...
Porphyrin and chlorophyll metabolism	-1.98	1.56e-3	23/43 (53.49%)	BLVRA;UGT2A3;UGT2B28;...
Metabolism of xenobiotics by cytochrome P450	-2.01	1.88e-3	49/77 (63.64%)	CYP1A2;UGT2A3;CYP3A4;...
Viral protein interaction with cytokine and cytokine re...	-2.02	2.34e-3	84/100 (84%)	TNFSF14;IL19;CCL18;...
IL-17 signaling pathway	-2.02	3.13e-3	84/94 (89.36%)	TBK1;FADD;TRADD;...
NF-kappa B signaling pathway	-2.08	4.69e-3	90/104 (86.54%)	NFKB1;TICAM1;RELA;...
Mineral absorption	-2.23	0.00e+0	48/60 (80%)	ATP1B2;ATP1A2;VDR;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	30uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼