Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM264B3)

• Drug Name: Dimenhydrinate Drug Info
• Synonyms: Gravamin (TN); Gravol (TN); Vertirosan (TN); Dimenhydrinate (JP15/USP/INN); 2-(diphenylmethoxy)-N,N-dimethylethanaminium 8-chloro-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-ide; 2-benzhydryloxyethyl(dimethyl)azanium; 8-chloro-1,3-dimethyl-2-oxopurin-6-olate; 8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione-2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
• Therapeutic Class: Antiemetics
• Cross-matching ID:
  PubChem CID: 10660
  ChEBI ID: CHEMBL1200406
  CAS Number: CAS 523-87-5
  TTD Drug ID: D0U8UV
  ACDINA Drug ID: D00201

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Bacterial invasion of epithelial cells	1.92	3.97e-2	59/77 (76.62%)	CRK;FN1;HCLS1;...
SNARE interactions in vesicular transport	-1.89	3.72e-2	19/33 (57.58%)	STX3;SNAP29;STX8;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	24H	Hide ▲