General Information of Drug (ID: DM29I0Y)

Drug Name
ANTHRAQUINONE Drug Info
Synonyms
84-65-1; 9,10-Anthraquinone; anthracene-9,10-dione; 9,10-Anthracenedione; Anthradione; Hoelite; 9,10-Dioxoanthracene; Corbit; Morkit; 9,10-Anthrachinon; Anthra-9,10-quinone; Anthrapel; 9,10-quinone; Anthrachinon; Caswell No. 052A; Anthraquinone [BSI:ISO]; UNII-030MS0JBDO; NSC 7957; Bis-alkylamino anthraquinone; 9,10-Anthrachinon [Czech]; CCRIS 649; 9,10-Anthracendion; Anthracene, 9,10-dihydro-9,10-dioxo-; CHEBI:40448; HSDB 2074; EINECS 201-549-0; Anthracene-9,10-quinone; EPA Pesticide Chemical Code 122701
Cross-matching ID
PubChem CID
6780
ChEBI ID
CHEMBL55659
CAS Number
CAS 84-65-1
TTD Drug ID
D0L5LN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Antigen processing and presentation 1.76 1.54e-1 60/78 (76.92%) HSPA6;TAPBP;HSPA1A;...
Graft-versus-host disease 1.56 5.23e-1 32/42 (76.19%) GZMB;PRF1;HLA-C;...
Allograft rejection 1.49 5.11e-1 32/38 (84.21%) GZMB;PRF1;HLA-C;...
African trypanosomiasis 1.46 4.96e-1 32/37 (86.49%) HBB;IDO1;VCAM1;...
Homologous recombination 1.42 5.91e-1 35/41 (85.37%) RPA2;BABAM2;NBN;...
Autoimmune thyroid disease 1.42 5.16e-1 46/53 (86.79%) GZMB;PRF1;HLA-C;...
Progesterone-mediated oocyte maturation 1.40 5.06e-1 75/100 (75%) IGF1;ADCY1;CDK2;...
Type I diabetes mellitus 1.39 4.83e-1 38/43 (88.37%) GZMB;PRF1;HLA-C;...
beta-Alanine metabolism 1.39 4.37e-1 25/30 (83.33%) CNDP2;ALDH7A1;ALDH3A1;...
Histidine metabolism 1.38 4.10e-1 16/22 (72.73%) CNDP2;AOC1;ALDH7A1;...
Protein digestion and absorption 1.35 4.56e-1 78/103 (75.73%) COL5A2;COL1A1;COL14A1;...
DNA replication 1.32 5.43e-1 34/36 (94.44%) RPA2;POLA1;MCM6;...
Legionellosis 1.31 5.32e-1 51/57 (89.47%) HSPA6;HSPA1A;CASP1;...
Leukocyte transendothelial migration 1.30 5.06e-1 90/114 (78.95%) VCAM1;PIK3CB;THY1;...
Mucin type O-glycan biosynthesis 1.30 4.86e-1 20/36 (55.56%) GALNT10;GALNT3;GALNT6;...
Hypertrophic cardiomyopathy 1.29 4.92e-1 81/90 (90%) IGF1;TNNC1;TTN;...
Endocrine and other factor-regulated calcium reabsorpti... 1.28 4.75e-1 49/53 (92.45%) ESR1;CLTB;KL;...
Synthesis and degradation of ketone bodies 1.28 4.50e-1 9/10 (90%) HMGCL;BDH1
Viral protein interaction with cytokine and cytokine re... 1.28 4.29e-1 84/100 (84%) PPBP;CCL5;CXCL14;...
Ribosome biogenesis in eukaryotes 1.28 4.21e-1 52/108 (48.15%) DROSHA;NAT10;MDN1;...
Apoptosis 1.28 4.08e-1 126/168 (75%) CSF2RB;GZMB;PRF1;...
Dilated cardiomyopathy 1.26 4.33e-1 86/96 (89.58%) IGF1;ADCY1;TNNC1;...
Notch signaling pathway 1.25 4.43e-1 49/59 (83.05%) NOTCH2;JAG2;NCOR2;...
Other types of O-glycan biosynthesis 1.25 4.27e-1 29/47 (61.7%) GALNT10;GALNT3;GALNT6;...
Longevity regulating pathway 1.24 4.37e-1 90/151 (59.6%) IGF1;HSPA6;HSPA1A;...
Melanoma 1.24 4.31e-1 68/72 (94.44%) IGF1;PDGFD;CDH1;...
Sphingolipid metabolism 1.21 4.92e-1 32/49 (65.31%) GALC;SPTLC2;CERS2;...
Salmonella infection 1.18 5.63e-1 198/249 (79.52%) AHNAK;AHNAK2;CASP1;...
Phagosome 1.18 5.45e-1 118/152 (77.63%) FCGR3B;SFTPA2;TUBB2A;...
Lysosome 1.12 6.20e-1 115/128 (89.84%) GALC;CLTB;CTSW;...
Choline metabolism in cancer -1.46 1.94e-1 84/98 (85.71%) EIF4EBP1;MAP2K1;MAPK8;...
Aldosterone-regulated sodium reabsorption -1.46 1.98e-1 34/37 (91.89%) SGK1;NR3C2;PIK3R1;...
mTOR signaling pathway -1.47 1.87e-1 114/154 (74.03%) FZD5;RRAGA;EIF4EBP1;...
PPAR signaling pathway -1.48 1.89e-1 66/74 (89.19%) SLC27A6;SCP2;ILK;...
Chemical carcinogenesis -1.49 1.76e-1 186/281 (66.19%) NFKB1;GSTA3;RB1;...
Pantothenate and CoA biosynthesis -1.49 1.83e-1 14/21 (66.67%) COASY;ALDH2;AASDHPPT;...
Mitophagy -1.49 1.89e-1 56/68 (82.35%) MITF;PINK1;RHOT1;...
Alcoholism -1.49 1.96e-1 86/186 (46.24%) TH;PRKACA;MAP2K1;...
Insulin signaling pathway -1.50 1.88e-1 121/137 (88.32%) AKT2;CBL;CBLB;...
Basal transcription factors -1.50 1.93e-1 37/45 (82.22%) TAF4B;GTF2H5;TBP;...
Neurotrophin signaling pathway -1.52 1.79e-1 107/119 (89.92%) RPS6KA3;AKT2;CALML4;...
MicroRNAs in cancer -1.52 1.86e-1 146/310 (47.1%) MAP2K1;TP63;CDK6;...
Retinol metabolism -1.53 1.84e-1 41/68 (60.29%) AOX1;DHRS9;UGT2B4;...
Drug metabolism -1.53 1.90e-1 78/151 (51.66%) XDH;AOX1;UGT2B4;...
Pentose and glucuronate interconversions -1.54 1.86e-1 17/34 (50%) RPE;UGT2B4;DCXR;...
Collecting duct acid secretion -1.55 1.90e-1 22/27 (81.48%) ATP4A;ATP6V1A;ATP6V0C;...
FoxO signaling pathway -1.55 2.00e-1 118/131 (90.08%) MAP2K1;CHUK;MAPK8;...
C-type lectin receptor signaling pathway -1.59 1.48e-1 93/104 (89.42%) RRAS2;SYK;AKT2;...
Metabolism of xenobiotics by cytochrome P450 -1.59 1.52e-1 49/77 (63.64%) UGT2B4;CYP1A2;GSTA4;...
Steroid hormone biosynthesis -1.60 1.48e-1 43/61 (70.49%) HSD17B7;COMT;CYP11B1;...
Nitrogen metabolism -1.61 1.46e-1 16/17 (94.12%) CPS1;CA4;GLUD2;...
Oxidative phosphorylation -1.62 1.52e-1 93/133 (69.92%) ATP6V1F;NDUFA9;ATP5F1C;...
Autophagy -1.63 1.42e-1 113/169 (66.86%) EIF2S1;RRAS2;DAPK2;...
Mineral absorption -1.64 1.44e-1 48/60 (80%) SLC30A1;HMOX1;SLC8A2;...
Renal cell carcinoma -1.65 1.39e-1 68/69 (98.55%) EPAS1;AKT2;TGFB2;...
Ferroptosis -1.67 1.35e-1 36/41 (87.8%) PCBP2;ATG5;SLC7A11;...
Complement and coagulation cascades -1.69 1.53e-1 76/85 (89.41%) CFHR2;CFHR4;C7;...
Non-alcoholic fatty liver disease -1.72 1.43e-1 126/155 (81.29%) CEBPA;NDUFB7;CYC1;...
Arginine biosynthesis -1.76 1.78e-1 17/22 (77.27%) GPT;CPS1;ARG1;...
Proximal tubule bicarbonate reclamation -1.84 1.23e-1 21/23 (91.3%) GLUD2;ATP1B3;PCK2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H