Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2AR7L)

Drug Name
Meloxicam Drug Info
Synonyms Meloxicam (SoluMatrix/arthritis); Meloxicam nanoformulation capsules (arthritis), iCeutica; Meloxicam (SoluMatrix/arthritis), iCeutica
Cross-matching ID
PubChem CID
54677470
ChEBI ID
CHEMBL6741
CAS Number
CAS 71125-38-7
TTD Drug ID
D0G7FJ
VARIDT Drug ID
DR00199
INTEDE Drug ID
DR1020
ACDINA Drug ID
D00393

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.26 0.00e+0 34/36 (94.44%) MCM5;PCNA;MCM6;...
Cell cycle 2.09 0.00e+0 110/124 (88.71%) SMC1A;MCM5;PCNA;...
Base excision repair 2.07 0.00e+0 29/33 (87.88%) PCNA;FEN1;POLE2;...
Nitrogen metabolism 1.96 4.03e-3 16/17 (94.12%) CA2;CA9;GLUL;...
Pyrimidine metabolism 1.91 1.29e-2 40/56 (71.43%) RRM2;TK1;TYMS;...
Mismatch repair 1.81 2.15e-2 22/23 (95.65%) PCNA;POLD1;RFC3;...
Oocyte meiosis 1.78 2.54e-2 90/129 (69.77%) SMC1A;ADCY1;CDK1;...
One carbon pool by folate 1.76 3.03e-2 15/20 (75%) MTHFD1;TYMS;ALDH1L1;...
Caffeine metabolism 1.75 2.69e-2 5/6 (83.33%) NAT1;CYP2A6;XDH
Epithelial cell signaling in Helicobacter pylori infect... -1.76 3.30e-2 62/70 (88.57%) IKBKB;JAM3;GIT1;...
Rheumatoid arthritis -1.83 1.35e-2 78/93 (83.87%) IL17A;IL15;CTSL;...
IL-17 signaling pathway -1.83 1.39e-2 84/94 (89.36%) IL1B;CXCL2;TAB2;...
Steroid biosynthesis -1.84 1.73e-2 19/20 (95%) CYP51A1;EBP;FDFT1;...
Vibrio cholerae infection -1.86 1.92e-2 44/50 (88%) ATP6V1E1;ATP6V0A4;ATP6AP1;...
Oxidative phosphorylation -1.88 2.31e-2 93/133 (69.92%) ATP5MC2;NDUFA4;COX7A2L;...
Mineral absorption -2.18 0.00e+0 48/60 (80%) TF;MT1M;FTL;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H