Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2C2OO)

Drug Name
Tiludronic acid Drug Info
Synonyms Skelid; Tiludronate disodium; ME-3737; SR-41319
Cross-matching ID
PubChem CID
60937
ChEBI ID
CHEMBL1350
CAS Number
CAS 89987-06-4
TTD Drug ID
D0Q8CS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 1.99 7.94e-3 48/60 (80%) MT1F;MT1HL1;MT1E;...
Tyrosine metabolism 1.88 2.38e-2 30/36 (83.33%) TYRP1;MAOB;ADH5;...
Pertussis -1.78 3.16e-2 64/76 (84.21%) SFTPA2;C2;IL1A;...
Tuberculosis -1.84 2.91e-2 159/180 (88.33%) RAB5B;ITGAX;MAPK14;...
Phagosome -1.90 2.10e-2 118/152 (77.63%) NCF4;FCGR2B;RAB7A;...
Leishmaniasis -1.95 2.33e-2 67/77 (87.01%) CYBB;NFKBIB;HLA-DRA;...
Bacterial invasion of epithelial cells -1.95 3.10e-2 59/77 (76.62%) CD2AP;CTNNA1;CRK;...
Complement and coagulation cascades -2.00 4.07e-2 76/85 (89.41%) C2;C1S;ITGB2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H