Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2C4RF)

Drug Name
BETRIXABAN Drug Info
Synonyms
Betrixaban; 330942-05-7; Bevyxxa; PRT054021; UNII-74RWP7W0J9; PRT 054021; 74RWP7W0J9; betrixaban maleate; Betrixaban [USAN:INN]; betrixaban/; Betrixaban (USAN); D0J0BU; SCHEMBL158591; QCR-99; GTPL9602; EX-A358; MolPort-009-682-948; ZINC3
Cross-matching ID
PubChem CID
10275777
ChEBI ID
CHEMBL512351
CAS Number
CAS 330942-05-7
TTD Drug ID
D0J0BU
VARIDT Drug ID
DR00216
ACDINA Drug ID
D00067

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.26 0.00e+0 44/46 (95.65%) PSMA6;PSMA5;PSMA1;...
Arginine biosynthesis 2.16 0.00e+0 17/22 (77.27%) CPS1;ARG2;GLUL;...
Prion disease 1.84 2.16e-2 209/273 (76.56%) PRKACB;CREB1;HSPA6;...
Parkinson disease 1.83 1.89e-2 176/249 (70.68%) PRKACB;PSMA6;CASP3;...
Pentose and glucuronate interconversions 1.82 1.73e-2 17/34 (50%) UGP2;DCXR;SORD;...
Huntington disease 1.81 1.62e-2 233/306 (76.14%) POLR2I;CREB1;GPX3;...
Ribosome biogenesis in eukaryotes 1.77 2.78e-2 52/108 (48.15%) POP7;NXT2;FBL;...
Alanine, aspartate and glutamate metabolism 1.75 2.97e-2 27/37 (72.97%) CPS1;GAD1;GLUL;...
Viral myocarditis 1.75 2.76e-2 53/60 (88.33%) CD40;HLA-DQA1;CAV1;...
Porphyrin and chlorophyll metabolism 1.74 2.92e-2 23/43 (53.49%) CP;PPOX;HCCS;...
DNA replication 1.71 3.73e-2 34/36 (94.44%) PCNA;POLE2;RPA3;...
Drug metabolism 1.70 3.87e-2 78/151 (51.66%) NME1;NAT1;ADH1C;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H