Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2CZFA)

• Drug Name: Etretinate Drug Info
• Synonyms: etretinate; 54350-48-0; Tegison; Ethyl etrinoate; Retinoid; Etretinatum; Etretinato; Ro 10-9359; Etretinatum [INN-Latin]; Etretinato [INN-Spanish]; UNII-65M2UDR9AG; CCRIS 3615; HSDB 7185; EINECS 259-119-3; NSC 297936; 65M2UDR9AG; Ro-10-9359; Tigason; CHEBI:4913; C23H30O3; Ethyl all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate; Ethyl (all-E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate; 3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonanetetraenoic acid ethy
• Cross-matching ID:
  PubChem CID: 5282375
  ChEBI ID: CHEMBL464
  CAS Number: CAS 54350-48-0
  TTD Drug ID: D0B1IP
  INTEDE Drug ID: DR0672

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Hypertrophic cardiomyopathy	2.17	0.00e+0	81/90 (90%)	SGCB;DES;ACTC1;...
Dilated cardiomyopathy	2.13	0.00e+0	86/96 (89.58%)	SGCB;DES;ACTC1;...
Allograft rejection	2.02	2.87e-3	32/38 (84.21%)	HLA-DQB1;PRF1;HLA-DMB;...
Intestinal immune network for IgA production	2.02	2.15e-3	38/48 (79.17%)	TGFB1;HLA-DQB1;IL6;...
Type I diabetes mellitus	2.00	1.72e-3	38/43 (88.37%)	CPE;PTPRN2;HLA-DQB1;...
Graft-versus-host disease	1.97	1.43e-3	32/42 (76.19%)	HLA-DQB1;PRF1;IL6;...
Leishmaniasis	1.91	2.46e-3	67/77 (87.01%)	NFKBIB;TGFB1;HLA-DQB1;...
Autoimmune thyroid disease	1.88	4.30e-3	46/53 (86.79%)	HLA-DQB1;PRF1;HLA-DMB;...
Viral myocarditis	1.84	6.69e-3	53/60 (88.33%)	SGCB;HLA-DQB1;PRF1;...
Cytosolic DNA-sensing pathway	1.76	2.15e-2	52/63 (82.54%)	NFKBIB;CCL4;CASP1;...
Inflammatory bowel disease	1.71	3.20e-2	58/65 (89.23%)	TGFB1;HLA-DQB1;IL6;...
Cell adhesion molecules	1.68	4.30e-2	118/148 (79.73%)	ICAM2;CADM1;SDC2;...
Primary bile acid biosynthesis	1.68	4.03e-2	15/17 (88.24%)	AMACR;CYP39A1;SLC27A5;...
Arrhythmogenic right ventricular cardiomyopathy	1.64	4.67e-2	70/77 (90.91%)	SGCB;DES;ATP2A3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼