Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2FGRT)

• Drug Name: Clavulanate Drug Info
• Synonyms: Clavulansaeure; Clavulox; Acide clavulanique; Acido clavulanico; Acidum clavulanicum; CLAVULANIC ACID; Clavulansaeure [INN]; Clavulinic Acid; Sodium Clavulanate; Antibiotic MM 14151; MM 14151; Acide clavulanique [INN-French]; Acido clavulanico [INN-Spanish]; Acidum clavulanicum [INN-Latin]; BRL-14151; Clavulanic acid (INN); Clavulanic acid [BAN:INN]; Clavulox (TN); MM-14151; (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (Z)-(2R,5R)-3-(2-Hydroxyethyliden)-7-oxo-4-oxa-1-azabicyclo(3.2.0)heptan-2-carbonsaeure; (Z)-(2R,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid; 3008-B; 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R-(2alpha,3Z,5alpha))
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 5280980
  ChEBI ID: CHEMBL777
  CAS Number: CAS 58001-44-8
  TTD Drug ID: D0X7JN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.18	0.00e+0	34/36 (94.44%)	RPA3;POLD1;RFC4;...
Mineral absorption	1.90	2.08e-2	48/60 (80%)	MT1M;MT1E;ATP2B1;...
Homologous recombination	1.88	1.66e-2	35/41 (85.37%)	RPA3;POLD1;RAD54B;...
Nicotine addiction	1.80	3.95e-2	32/40 (80%)	GABRA1;GABRD;SLC17A7;...
Steroid biosynthesis	-1.88	3.94e-2	19/20 (95%)	CYP27B1;MSMO1;DHCR7;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲