Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2H8FZ)

Drug Name
TAK-700 Drug Info
Synonyms Orteronel
Cross-matching ID
PubChem CID
9883029
ChEBI ID
CHEMBL94965
TTD Drug ID
D0X3OI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 2.01 0.00e+0 110/124 (88.71%) CDC20;CCNB2;BUB1;...
Fanconi anemia pathway 1.94 0.00e+0 36/54 (66.67%) FANCI;REV3L;RPA1;...
Fatty acid biosynthesis 1.81 2.53e-2 16/18 (88.89%) HSD17B8;FASN;ACSL1;...
Oocyte meiosis 1.79 2.37e-2 90/129 (69.77%) CDC20;CCNB2;BUB1;...
Spliceosome 1.71 4.56e-2 101/150 (67.33%) PUF60;CHERP;SART1;...
Pertussis -1.73 1.30e-2 64/76 (84.21%) CALML4;ITGB1;IL10;...
Platelet activation -1.74 1.31e-2 106/124 (85.48%) GNAI3;FCGR2A;RHOA;...
Fluid shear stress and atherosclerosis -1.74 1.27e-2 123/139 (88.49%) MAP3K5;MAP2K4;CALML4;...
Human cytomegalovirus infection -1.74 1.31e-2 201/225 (89.33%) GNB1;GNG3;AKAP13;...
Inflammatory bowel disease -1.75 1.22e-2 58/65 (89.23%) IFNGR1;TLR2;HLA-DQB1;...
Gap junction -1.76 1.22e-2 72/88 (81.82%) HTR2A;PRKCB;GNAI3;...
Viral myocarditis -1.76 1.27e-2 53/60 (88.33%) HLA-F;HLA-DQB1;CD28;...
Autoimmune thyroid disease -1.78 1.05e-2 46/53 (86.79%) HLA-F;HLA-DQB1;CD28;...
Rap1 signaling pathway -1.79 8.65e-3 184/210 (87.62%) AKT3;MAPK3;FGF5;...
Asthma -1.80 7.85e-3 25/31 (80.65%) HLA-DQB1;HLA-DPB1;FCER1A;...
Renin secretion -1.80 8.24e-3 61/69 (88.41%) KCNMA1;EDN3;CTSB;...
Pathogenic Escherichia coli infection -1.86 3.34e-3 152/197 (77.16%) ITGB1;CLDN4;FADD;...
IL-17 signaling pathway -1.86 3.52e-3 84/94 (89.36%) FADD;TNFAIP3;CCL11;...
Viral protein interaction with cytokine and cytokine re... -1.88 3.73e-3 84/100 (84%) CCL1;CCR2;IL24;...
Gastric acid secretion -1.88 3.17e-3 63/76 (82.89%) PRKCB;CCKBR;GNAI3;...
Mucin type O-glycan biosynthesis -1.89 1.69e-3 20/36 (55.56%) GALNT10;GALNT6;GALNT3;...
MAPK signaling pathway -1.89 1.81e-3 272/294 (92.52%) PLA2G4A;FGFR3;TGFB3;...
Mineral absorption -1.93 9.75e-4 48/60 (80%) MT2A;MT1H;FXYD2;...
Parathyroid hormone synthesis, secretion and action -1.93 1.06e-3 98/106 (92.45%) SLC34A2;MMP14;CREB3L2;...
TNF signaling pathway -1.96 0.00e+0 103/112 (91.96%) RPS6KA4;MAP3K5;MAP2K4;...
Allograft rejection -1.98 0.00e+0 32/38 (84.21%) HLA-F;HLA-DQB1;CD28;...
Type I diabetes mellitus -1.98 0.00e+0 38/43 (88.37%) IL2;HLA-E;HLA-DOA;...
Th17 cell differentiation -1.98 0.00e+0 95/107 (88.79%) STAT5B;MAPK9;NFKB1;...
Intestinal immune network for IgA production -2.02 0.00e+0 38/48 (79.17%) ICOS;ITGB7;HLA-DQB1;...
Cytokine-cytokine receptor interaction -2.04 0.00e+0 246/295 (83.39%) IFNGR1;CSH1;TNFSF9;...
Graft-versus-host disease -2.07 0.00e+0 32/42 (76.19%) HLA-F;HLA-DQB1;CD28;...
Antigen processing and presentation -2.15 0.00e+0 60/78 (76.92%) LGMN;HSP90AB1;CD8B;...
Rheumatoid arthritis -2.23 0.00e+0 78/93 (83.87%) TLR2;HLA-DQB1;CXCL5;...
Ferroptosis -2.36 0.00e+0 36/41 (87.8%) SLC3A2;STEAP3;TF;...
Hematopoietic cell lineage -2.37 0.00e+0 90/99 (90.91%) CSF2RA;ANPEP;GYPA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 40uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 40uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 40uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 40uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 40uM 6H
MDST8 CVCL_1400 Homo sapiens 40uM 6H
NCI-H508 CVCL_1561 Homo sapiens 40uM 6H
SNU-1040 CVCL_5001 Homo sapiens 40uM 6H
SNU-C4 CVCL_5008 Homo sapiens 40uM 6H
SNU-C5 CVCL_5009 Homo sapiens 40uM 6H
SW480 CVCL_0546 Homo sapiens 40uM 6H
SW620 CVCL_0547 Homo sapiens 40uM 6H
SW948 CVCL_0550 Homo sapiens 40uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 40uM 6H
HT115 CVCL_1294 Homo sapiens 40uM 6H
RKO CVCL_0504 Homo sapiens 40uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 40uM 6H
SNG-M CVCL_1707 Homo sapiens 40uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 40uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 40uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 40uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 40uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 40uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 40uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 40uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 40uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 40uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 40uM 6H
HCC515 CVCL_5134 Homo sapiens 40uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 40uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 40uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 40uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 40uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 40uM 6H
OV7 CVCL_1623 Homo sapiens 40uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 40uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 40uM 6H
RMUG-S CVCL_1666 Homo sapiens 40uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 40uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 40uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 40uM 6H
PL-21 CVCL_2161 Homo sapiens 40uM 6H
SKM-1 CVCL_0010 Homo sapiens 40uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 40uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 40uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 40uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 40uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 40uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 40uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 40uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H