Details of the Drug Pharmacogenomic Perturbation Atlas

Triamterene Drug Info

Ademin; Ademine; Amteren; Anjal; Dazid; Diarol; Dinazide; Diren; Ditak; Diucelpin; Diurene; Diutensat; Diuteren; Dyberzide; Dyren; Dyrenium; Dytac; Dytenzide; Esiteren; Hidiurese; Hydrene; Hypertorr; Isobar; Jatropur; Jenateren; Kalspare; Masuharmin; Nephral; Noridil; Noridyl; Pterofen; Pterophene; Renezide; Reviten; Taturil; Teriam; Teridin; Triamizide; Triampur; Triamteren; Triamterena; Triamterenum; Triamteril; Triamterine; Triamthiazid; Tricilone; Trispan; Triteren; Triurene; Trizid; Turfa; Uretren; Urocaudal; Goldshield Brand of Triamterene; Jorba Brand of Triamterene; Pter ophene; SmithKline Beecham Brand of Triamterene; TRIAMTERENE USP; Thiazid Wolff; Triamteril complex; Wellspring Brand of Triamterene; Fluss 40; SKF 8542; T 4143; Ademin(e); Apo-triazide; Dyrenium (TN); Pteridine deriv. 11; SALI-PUREN; SK&F 8542; SK-8542; Tri-Span; Triamterena [INN-Spanish]; Triamterenum [INN-Latin]; SK&F-8542; Triamterene (JP15/USP/INN); Triamterene [USAN:INN:BAN:JAN]; 2,4,7-Triamino-6-fenilpteridina; 2,4,7-Triamino-6-fenilpteridina [Italian]; 2,4,7-Triamino-6-phenylpteridine; 6-PHENYL-2,4,7-TRIAMINO PTERIDINE; 6-Phenyl-2,4,7-pteridinetriamine; 6-Phenyl-2,4,7-triaminopteridine; 6-phenylpteridine-2,4,7-triamine

Therapeutic Class

Cross-matching ID

PubChem CID

5546

ChEBI ID

CHEMBL9671

CAS Number

CAS 396-01-0

TTD Drug ID

D00NKB

VARIDT Drug ID

DR01341

INTEDE Drug ID

DR1636

ACDINA Drug ID

D00700

General Information of Drug (ID: DM2HU9I)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Valine, leucine and isoleucine degradation	1.76	2.05e-1	42/48 (87.5%)	HMGCS2;ACAT2;DLD;...
Tryptophan metabolism	1.73	1.52e-1	35/42 (83.33%)	ACAT2;KYNU;DLD;...
Synthesis and degradation of ketone bodies	1.71	1.32e-1	9/10 (90%)	HMGCS2;ACAT2;BDH2;...
Non-homologous end-joining	1.71	1.01e-1	11/13 (84.62%)	MRE11;LIG4;DNTT
Peroxisome	1.69	1.00e-1	72/82 (87.8%)	PEX11A;FAR2;SOD2;...
Nitrogen metabolism	1.67	9.13e-2	16/17 (94.12%)	CA2;GLUL;CPS1;...
Drug metabolism	1.67	8.04e-2	78/151 (51.66%)	DPYD;ADH5;GSTM3;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1.63	9.98e-2	20/26 (76.92%)	PIGB;PIGP;MPPE1;...
Lysosome	1.56	1.64e-1	115/128 (89.84%)	GM2A;AGA;HEXB;...
Butanoate metabolism	1.55	1.54e-1	23/28 (82.14%)	HMGCS2;ACAT2;BDH2;...
Pentose and glucuronate interconversions	1.52	1.72e-1	17/34 (50%)	SORD;UGT2B28;AKR1B1;...
Phototransduction	1.51	1.69e-1	21/29 (72.41%)	SLC24A1;CALML3;GNB1;...
Glycine, serine and threonine metabolism	1.48	2.01e-1	31/40 (77.5%)	GATM;DLD;PSAT1;...
Mineral absorption	1.47	2.06e-1	48/60 (80%)	SLC39A4;STEAP1;FTH1;...
Cysteine and methionine metabolism	1.46	1.94e-1	43/50 (86%)	BCAT1;GSS;PSAT1;...
Glycolysis / Gluconeogenesis	1.45	2.00e-1	56/67 (83.58%)	ADH5;DLD;ALDH2;...
Oxidative phosphorylation	1.45	1.92e-1	93/133 (69.92%)	TCIRG1;ATP5F1C;ATP5PD;...
Fructose and mannose metabolism	1.44	1.98e-1	30/33 (90.91%)	SORD;PFKM;AKR1B1;...
Tyrosine metabolism	1.42	2.04e-1	30/36 (83.33%)	ADH5;AOX1;GSTZ1;...
Pentose phosphate pathway	1.42	1.96e-1	25/30 (83.33%)	PFKM;PRPS2;RPIA;...
Glyoxylate and dicarboxylate metabolism	1.41	2.00e-1	23/30 (76.67%)	ACAT2;DLD;GLUL;...
Ascorbate and aldarate metabolism	1.41	1.97e-1	15/30 (50%)	UGT2B28;ALDH2;ALDH3A2;...
Primary bile acid biosynthesis	1.40	1.99e-1	15/17 (88.24%)	CH25H;ACOT8;CYP39A1;...
Alanine, aspartate and glutamate metabolism	1.39	2.02e-1	27/37 (72.97%)	ASS1;GLUL;CPS1;...
Collecting duct acid secretion	1.39	1.98e-1	22/27 (81.48%)	CA2;TCIRG1;ATP6V1B2;...
IL-17 signaling pathway	1.39	1.92e-1	84/94 (89.36%)	CXCL8;S100A7;LCN2;...
Glutathione metabolism	1.39	1.92e-1	43/57 (75.44%)	LAP3;CHAC1;GSTM3;...
Other glycan degradation	1.37	2.05e-1	13/18 (72.22%)	AGA;HEXB;GLB1;...
Alcoholism	1.37	2.03e-1	86/186 (46.24%)	GNAI1;PKIA;ADORA2B;...
Arginine biosynthesis	1.35	2.16e-1	17/22 (77.27%)	ASS1;GLUL;CPS1;...
Longevity regulating pathway	-1.33	3.65e-1	90/151 (59.6%)	IRS2;FOXA2;STK11;...
Hepatitis B	-1.34	3.61e-1	151/162 (93.21%)	MAPK10;IRAK1;MAPK9;...
Protein digestion and absorption	-1.37	3.52e-1	78/103 (75.73%)	SLC7A8;SLC3A1;CTRL;...
Wnt signaling pathway	-1.37	3.49e-1	124/166 (74.7%)	PPP3R1;ROR2;LEF1;...
Neutrophil extracellular trap formation	-1.38	3.58e-1	101/189 (53.44%)	AKT2;MAPK13;RAF1;...
Insulin secretion	-1.40	3.28e-1	75/86 (87.21%)	STX1A;ATP1B2;KCNMB3;...
AMPK signaling pathway	-1.40	3.29e-1	106/120 (88.33%)	PFKFB2;PFKFB1;CFTR;...
Inositol phosphate metabolism	-1.42	3.15e-1	66/73 (90.41%)	IPPK;PLCG1;PI4KB;...
Phagosome	-1.44	2.77e-1	118/152 (77.63%)	HLA-DMB;SEC61A1;CD209;...
Focal adhesion	-1.46	2.40e-1	180/201 (89.55%)	PAK6;PAK4;PAK2;...
Regulation of lipolysis in adipocytes	-1.47	2.44e-1	52/55 (94.55%)	LIPE;AKT1;CGA;...
Shigellosis	-1.47	2.33e-1	180/246 (73.17%)	MALT1;TNFRSF1A;AKT2;...
Ribosome biogenesis in eukaryotes	-1.48	2.40e-1	52/108 (48.15%)	MDN1;MPHOSPH10;DKC1;...
Tight junction	-1.49	2.36e-1	130/169 (76.92%)	PRKCI;STK11;ARPC2;...
Spliceosome	-1.50	2.46e-1	101/150 (67.33%)	SF3A2;RBM25;SNRNP40;...
Protein processing in endoplasmic reticulum	-1.50	2.59e-1	127/171 (74.27%)	EIF2AK2;EIF2AK1;PRKCSH;...
GnRH secretion	-1.50	2.64e-1	60/64 (93.75%)	PRKCB;GABBR1;ITPR2;...
Salivary secretion	-1.50	2.75e-1	76/93 (81.72%)	CST2;GUCY1A2;ATP1B2;...
Th1 and Th2 cell differentiation	-1.52	2.54e-1	80/92 (86.96%)	RUNX3;NFKBIA;NFKBIE;...
Phosphatidylinositol signaling system	-1.54	2.39e-1	82/97 (84.54%)	DGKA;DGKG;CDS1;...
Platelet activation	-1.57	1.96e-1	106/124 (85.48%)	FYN;BTK;STIM1;...
ECM-receptor interaction	-1.60	1.73e-1	80/88 (90.91%)	ITGB7;COL4A6;COL4A1;...
Ovarian steroidogenesis	-1.60	1.78e-1	41/51 (80.39%)	LHB;AKR1C3;LDLR;...
Proteoglycans in cancer	-1.61	1.87e-1	172/205 (83.9%)	ITGA5;DDX5;ARHGEF1;...
Proteasome	-1.64	1.61e-1	44/46 (95.65%)	PSMA3;PSMA5;PSME2;...
Type II diabetes mellitus	-1.64	1.84e-1	42/46 (91.3%)	HK2;IRS2;CACNA1B;...
Spinocerebellar ataxia	-1.65	2.14e-1	128/143 (89.51%)	TBP;AKT2;ATP2A3;...
Cortisol synthesis and secretion	-1.68	2.37e-1	58/65 (89.23%)	ADCY6;SCARB1;STAR;...
Cholesterol metabolism	-1.72	1.84e-1	44/50 (88%)	LRP1;APOH;STARD3;...
Notch signaling pathway	-1.87	8.57e-2	49/59 (83.05%)	NOTCH4;DTX3;NOTCH3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H

MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 2.22uM	24H

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HEK293	CVCL_0045	Homo sapiens	0.04uM - 10uM	24H

HEK293T	CVCL_0063	Homo sapiens	0.125uM - 10uM	6H, 24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.04uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H

VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.04uM - 10uM	24H