Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2I8NT)

Drug Name
Avosentan Drug Info
Synonyms
SPP 301; SPP301; Ro 67-0565; N-[6-methoxy-5-(2-methoxyphenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-5-methyl-pyridine-2-sulfonamide; 5-methylpyridine-2-sulfonic acid (6-methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)pyrimidin-4-yl)amide
Cross-matching ID
PubChem CID
9912992
ChEBI ID
CHEMBL3989834
CAS Number
CAS 290815-26-8
TTD Drug ID
D0J2IH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.44 0.00e+0 34/36 (94.44%) MCM5;RFC2;RPA3;...
Mismatch repair 2.04 0.00e+0 22/23 (95.65%) RFC2;RPA3;RFC3;...
Citrate cycle (TCA cycle) 1.99 2.71e-3 30/30 (100%) ACLY;OGDH;ACO2;...
Terpenoid backbone biosynthesis 1.92 4.06e-3 18/22 (81.82%) HMGCS1;HMGCS2;FDPS;...
Fatty acid elongation 1.91 3.25e-3 19/27 (70.37%) ELOVL6;HSD17B12;ACOT7;...
Fatty acid biosynthesis 1.89 2.71e-3 16/18 (88.89%) ACACA;ACSL3;MCAT;...
Proteasome 1.88 2.32e-3 44/46 (95.65%) PSMD14;PSMD1;PSMD3;...
Oxidative phosphorylation 1.87 2.03e-3 93/133 (69.92%) ATP6V1E1;NDUFA6;NDUFS6;...
Steroid biosynthesis 1.86 1.81e-3 19/20 (95%) MSMO1;NSDHL;EBP;...
Ribosome biogenesis in eukaryotes 1.81 6.50e-3 52/108 (48.15%) NXT1;NAT10;DROSHA;...
Pentose phosphate pathway 1.80 6.65e-3 25/30 (83.33%) PFKM;FBP1;PFKL;...
Cholesterol metabolism 1.76 1.22e-2 44/50 (88%) CD36;SCARB1;LRPAP1;...
Folate biosynthesis 1.72 1.94e-2 23/26 (88.46%) QDPR;GGH;AKR1C3;...
Cell cycle 1.72 1.92e-2 110/124 (88.71%) CDK1;MCM5;CCNE2;...
Pyrimidine metabolism 1.65 3.96e-2 40/56 (71.43%) NME1;RRM2;TYMP;...
Sulfur relay system 1.65 3.71e-2 5/8 (62.5%) TST
Nucleotide excision repair 1.63 4.50e-2 40/47 (85.11%) RFC2;RPA3;RFC3;...
Hepatitis C 1.63 4.29e-2 139/157 (88.54%) IFIT1;MX1;OAS1;...
Influenza A 1.61 4.88e-2 156/172 (90.7%) MX1;OAS1;OAS3;...
Glycine, serine and threonine metabolism 1.60 4.92e-2 31/40 (77.5%) PSPH;GATM;DLD;...
Glutathione metabolism 1.60 4.76e-2 43/57 (75.44%) CHAC1;GGCT;LAP3;...
Diabetic cardiomyopathy 1.58 4.95e-2 162/203 (79.8%) AGT;PPIF;MPC2;...
FoxO signaling pathway -1.70 3.90e-2 118/131 (90.08%) FOXO3;PIK3CD;MAPK3;...
Mitophagy -1.70 3.93e-2 56/68 (82.35%) SP1;TFEB;TBC1D15;...
Parathyroid hormone synthesis, secretion and action -1.72 3.44e-2 98/106 (92.45%) PLCB4;ATF2;MMP15;...
AGE-RAGE signaling pathway in diabetic complications -1.72 3.87e-2 97/100 (97%) PLCB4;VEGFC;COL4A2;...
Hypertrophic cardiomyopathy -1.73 3.92e-2 81/90 (90%) EDN1;TPM1;DES;...
Graft-versus-host disease -1.75 3.78e-2 32/42 (76.19%) HLA-F;HLA-DRA;HLA-DPB1;...
ECM-receptor interaction -1.78 3.81e-2 80/88 (90.91%) GP5;ITGA4;TNC;...
Focal adhesion -1.78 4.77e-2 180/201 (89.55%) COL6A2;MYL2;ITGB5;...
Proteoglycans in cancer -1.93 3.97e-3 172/205 (83.9%) VEGFA;DDX5;RDX;...
Legionellosis -1.95 5.96e-3 51/57 (89.47%) TLR5;CXCL8;CXCL1;...
Retinol metabolism -2.15 0.00e+0 41/68 (60.29%) ADH5;DHRS3;UGT2B4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.04uM - 10uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H