Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2K6I8)

• Drug Name: Ryanodine Drug Info
• Synonyms: ryanodine; Ryanodin; 15662-33-6; Ryania; Ryanodol, 3-(1H-pyrrole-2-carboxylate); Ryanadol; (3S,4R,4aR,6S,6aR,7S,8R,8aS,8bR,9S,9aS)-4,6,7,8a,8b,9a-hexahydroxy-7-isopropyl-3,6a,9-trimethyldodecahydro-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl 1H-pyrrole-2-carboxylate; (3S,4R,4aR,6S,6aR,7S,8R,8aS,8bR,9S,9aS)-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(propan-2-yl)dodecahydro-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl 1H-pyrrole-2-carboxylate; 3-(1H-pyrrole-2-carboxylate; Ryanodine High Purity
• Cross-matching ID:
  PubChem CID: 11317883
  ChEBI ID: CHEMBL8925
  CAS Number: CAS 15662-33-6
  TTD Drug ID: D08LUJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ferroptosis	-1.72	4.93e-2	36/41 (87.8%)	CYBB;PRNP;TP53;...
Collecting duct acid secretion	-1.74	4.35e-2	22/27 (81.48%)	ATP6V1E1;ATP6V0A4;ATP6V0A1;...
Cocaine addiction	-1.74	4.97e-2	42/49 (85.71%)	GRIA2;FOSB;ATF4;...
Retinol metabolism	-1.78	3.20e-2	41/68 (60.29%)	UGT2B28;CYP3A7;UGT2B17;...
Folate biosynthesis	-1.85	7.20e-3	23/26 (88.46%)	ALPP;MOCS1;TH;...
Protein processing in endoplasmic reticulum	-1.87	6.00e-3	127/171 (74.27%)	SSR3;EIF2AK1;SEC61B;...
Vibrio cholerae infection	-1.87	8.00e-3	44/50 (88%)	SEC61B;KDELR2;TJP1;...
N-Glycan biosynthesis	-1.91	6.00e-3	38/50 (76%)	DDOST;MGAT4A;B4GALT1;...
Mitophagy	-2.01	0.00e+0	56/68 (82.35%)	CITED2;TBK1;TBC1D15;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼