Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2KEW6)

Drug Name
3R14S-OCHRATOXIN A Drug Info
Synonyms
Ochratoxin A; OCHRATOXIN A; Antibiotic 9663; 303-47-9; Phenylalanine - ochratoxin A; NCI-C56586; C20H18ClNO6; CHEBI:7719; RWQKHEORZBHNRI-BMIGLBTASA-N; Ochratoxin A, aspergillus ochraceus; Ochratoxin A-BSA conjugate from Aspergillus ochraceus; N-(((3R)-5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenyl-L-alanine; (-)-N-((5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenylalanine; NSC 201422; UNII-1779SX6LUY; OTA; ochratoxin A
Cross-matching ID
PubChem CID
442530
ChEBI ID
CHEMBL589366
CAS Number
CAS 303-47-9
TTD Drug ID
D0KN6Q
VARIDT Drug ID
DR00229

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Complement and coagulation cascades 2.20 0.00e+0 76/85 (89.41%) CFI;PLAT;SERPINA5;...
Nitrogen metabolism 2.03 0.00e+0 16/17 (94.12%) CA12;GLUD1;CA2;...
Amoebiasis 1.95 7.48e-3 99/102 (97.06%) LAMB1;SERPINB9;LAMC1;...
Adherens junction 1.95 5.61e-3 63/71 (88.73%) CDH1;LEF1;YES1;...
Platelet activation 1.89 8.98e-3 106/124 (85.48%) GUCY1A1;F2R;GNAS;...
Bacterial invasion of epithelial cells 1.87 1.12e-2 59/77 (76.62%) CDH1;RAC1;CRK;...
Bile secretion 1.86 9.62e-3 68/90 (75.56%) AQP1;GNAS;CA2;...
Endocrine and other factor-regulated calcium reabsorpti... 1.86 8.42e-3 49/53 (92.45%) ESR1;RAB11A;GNAS;...
Glycine, serine and threonine metabolism 1.82 1.12e-2 31/40 (77.5%) GATM;GLDC;SDS;...
Systemic lupus erythematosus 1.79 1.57e-2 45/135 (33.33%) C7;C1QB;C9;...
mRNA surveillance pathway 1.75 2.55e-2 71/98 (72.45%) RBM8A;SAP18;PPP2R5C;...
Aldosterone-regulated sodium reabsorption 1.72 3.37e-2 34/37 (91.89%) SCNN1A;INSR;PRKCA;...
Regulation of actin cytoskeleton 1.69 4.14e-2 185/218 (84.86%) CYFIP1;PDGFRA;F2R;...
Tight junction 1.68 4.01e-2 130/169 (76.92%) RAC1;CDC42;TIAM1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H