Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2LJFZ)

• Drug Name: 4-hydroxy-2-nonenal Drug Info
• Synonyms: 4-Hydroxynonenal; 4-Hydroxy-2-nonenal; 4-hydroxynon-2-enal; trans-4-Hydroxy-2-nonenal; 4-Hydroxy-2,3-nonenal; 4-HNE; 75899-68-2; 4-hydroxy-2E-nonenal; (E)-4-hydroxynon-2-enal; CCRIS 9028; CCRIS 1781; 29343-52-0; 128946-65-6; 2-NONENAL, 4-HYDROXY-; HNE; (E)-4-hydroxy-2-nonenal; (2E)-4-hydroxynon-2-enal; (2E)-4-Hydroxy-2-nonenal; CHEMBL454280; CHEBI:58968; C9H16O2; (+/-)4-HYDROXYNON-2-ENAL; NCGC00161254-02; 4-hydroxynonen-2-al; CHEBI:32585; CCRIS 6927; 4 hydroxynonenal; (E)-4-Hydroxynonenal; AC1Q2VOQ; 4HNE; SCHEMBL3920; AC1Q6PP5; AC1NR22M
• Cross-matching ID:
  PubChem CID: 5283344
  ChEBI ID: CHEMBL58968
  CAS Number: CAS 75899-68-2
  TTD Drug ID: D08UPA
  INTEDE Drug ID: DR2062

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Protein processing in endoplasmic reticulum	1.98	3.27e-2	127/171 (74.27%)	HSPA6;RAD23B;HERPUD1;...
IL-17 signaling pathway	1.96	1.63e-2	84/94 (89.36%)	S100A8;S100A9;CEBPB;...
Metabolism of xenobiotics by cytochrome P450	1.91	1.45e-2	49/77 (63.64%)	AKR1C1;GSTA1;GSTP1;...
Drug metabolism	1.85	2.45e-2	78/151 (51.66%)	MPO;CES1;MAOA;...
Glutathione metabolism	1.83	2.40e-2	43/57 (75.44%)	GCLM;ANPEP;GSTA1;...
Folate biosynthesis	1.81	2.90e-2	23/26 (88.46%)	AKR1B10;AKR1C3;AKR1B1;...
Ferroptosis	1.78	3.11e-2	36/41 (87.8%)	HMOX1;GCLM;SLC7A11;...
Staphylococcus aureus infection	1.76	4.35e-2	72/95 (75.79%)	DEFA4;KRT18;KRT16;...
Arginine biosynthesis	1.73	4.60e-2	17/22 (77.27%)	ARG2;ARG1;GLUD1;...
Retinol metabolism	1.72	4.90e-2	41/68 (60.29%)	HSD17B6;ALDH1A1;CYP3A4;...
Hypertrophic cardiomyopathy	-1.75	4.79e-2	81/90 (90%)	ITGA5;ITGB1;ITGA7;...
Cardiac muscle contraction	-1.96	3.04e-3	64/87 (73.56%)	SLC9A1;COX6A2;CACNG2;...
Dilated cardiomyopathy	-2.01	0.00e+0	86/96 (89.58%)	ITGA5;ITGB1;ITGA7;...
ECM-receptor interaction	-2.10	0.00e+0	80/88 (90.91%)	FN1;ITGA5;ITGB1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼