Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2LZ8F)

Drug Name
Taurocholic Acid Drug Info
Synonyms
Taurocholic acid; TAUROCHOLIC ACID; Taurocholate; Cholyltaurine; Cholaic acid; N-Choloyltaurine; Cholic acid taurine conjugate; 81-24-3; Taurine, N-choloyl-; Acidum cholatauricum; Taurine Cholate; UNII-5E090O0G3Z; HSDB 832; C26H45NO7S; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid 24-taurine; NSC25505; EINECS 201-336-2; NSC 25505; Ethanesulfonic acid, 2-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-; 2-((3-alpha,7-alpha,12-alpha-Trihydroxy-24-oxo-5-be ta-cholan-24-yl)amino)ethanesulfonic acid; [3H]taurocholic acid
Cross-matching ID
PubChem CID
6675
ChEBI ID
CHEMBL224867
CAS Number
CAS 81-24-3
TTD Drug ID
D09NTG
VARIDT Drug ID
DR01121

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spinocerebellar ataxia -1.72 4.64e-2 128/143 (89.51%) CYCS;ATP2A2;MAP3K5;...
Rheumatoid arthritis -1.77 3.48e-2 78/93 (83.87%) ATP6V0A1;IL6;TGFB1;...
Protein processing in endoplasmic reticulum -1.77 3.87e-2 127/171 (74.27%) EIF2AK1;HSP90AA1;EDEM3;...
Protein digestion and absorption -1.78 4.04e-2 78/103 (75.73%) MEP1A;COL18A1;ATP1A1;...
Ferroptosis -1.85 1.96e-2 36/41 (87.8%) NCOA4;CYBB;TF;...
Phagosome -1.90 1.04e-2 118/152 (77.63%) RAB5A;C3;ATP6V0A2;...
Proximal tubule bicarbonate reclamation -1.95 9.96e-3 21/23 (91.3%) CA4;ATP1A1;ATP1B2;...
Hematopoietic cell lineage -1.98 9.33e-3 90/99 (90.91%) IL11;IL5;DNTT;...
PPAR signaling pathway -2.00 1.24e-2 66/74 (89.19%) FABP1;SLC27A2;LPL;...
Bile secretion -2.00 1.87e-2 68/90 (75.56%) ABCG2;AQP4;UGT2B15;...
Mineral absorption -2.24 1.24e-2 48/60 (80%) TRPV6;MT1H;HEPH;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 6.66uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H