Details of the Drug Pharmacogenomic Perturbation Atlas

Ciclesonide Drug Info

Alvesco; Omnair; Omnaris; Osonase; Osonide; Alvesco HFA; Ciclesonide [INN]; Omnaris HFA; RPR 251526; Alvesco (TN); BTR-15; BTR-15K; BY-9010; BYK-20426; KS-1165; Omnaris (TN); Omniair (TN); TBN-15; B-9207-015; Ciclesonide (JAN/USAN/INN); (R)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde, 21-isobutyrate

Therapeutic Class

Antiallergic Agents

Cross-matching ID

PubChem CID

6918155

ChEBI ID

CHEMBL2040682

CAS Number

CAS 126544-47-6

TTD Drug ID

D0K7HU

VARIDT Drug ID

DR01408

INTEDE Drug ID

DR0319

General Information of Drug (ID: DM2NA4K)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Oxidative phosphorylation	2.33	0.00e+0	93/133 (69.92%)	COX5B;NDUFA6;NDUFA7;...
Complement and coagulation cascades	2.21	0.00e+0	76/85 (89.41%)	C3;SERPINE1;F3;...
Drug metabolism	2.02	3.13e-3	78/151 (51.66%)	MAOA;NAT1;ADH1B;...
Staphylococcus aureus infection	2.00	2.35e-3	72/95 (75.79%)	C3;C1QB;C1QA;...
Sulfur metabolism	2.00	1.88e-3	9/10 (90%)	TST;SQOR;MPST;...
Non-alcoholic fatty liver disease	1.97	3.13e-3	126/155 (81.29%)	COX5B;NDUFA6;CYCS;...
Peroxisome	1.95	2.68e-3	72/82 (87.8%)	IDH2;PEX11A;PXMP4;...
Ribosome	1.95	2.35e-3	113/158 (71.52%)	MRPS16;RPS5;MRPL15;...
Mineral absorption	1.94	2.09e-3	48/60 (80%)	MT1E;MT1M;MT1G;...
Nicotinate and nicotinamide metabolism	1.92	1.88e-3	25/35 (71.43%)	NNMT;NAMPT;NMRK1;...
Phenylalanine metabolism	1.90	1.71e-3	14/17 (82.35%)	MAOA;GOT1;GLYAT;...
Tyrosine metabolism	1.90	1.57e-3	30/36 (83.33%)	MAOA;ADH1B;ADH5;...
Parkinson disease	1.87	2.89e-3	176/249 (70.68%)	DUSP1;MAOA;BCL2L1;...
Metabolism of xenobiotics by cytochrome P450	1.80	1.21e-2	49/77 (63.64%)	EPHX1;ADH1B;ADH5;...
Glycine, serine and threonine metabolism	1.80	1.13e-2	31/40 (77.5%)	MAOA;CBS;BHMT;...
DNA replication	1.75	1.76e-2	34/36 (94.44%)	RPA3;RNASEH2A;POLE2;...
Arachidonic acid metabolism	1.74	1.71e-2	48/61 (78.69%)	PLAAT3;ALOX5;AKR1C3;...
Thermogenesis	1.73	2.04e-2	173/232 (74.57%)	COX5B;RPS6KA2;NDUFA6;...
Fatty acid degradation	1.70	2.37e-2	40/43 (93.02%)	ACAA2;ADH1B;ADH5;...
Huntington disease	1.70	2.68e-2	233/306 (76.14%)	POLR2I;COX5B;NDUFA6;...
Arginine biosynthesis	1.69	2.77e-2	17/22 (77.27%)	ASS1;GLUL;GOT1;...
p53 signaling pathway	1.66	3.59e-2	63/73 (86.3%)	SERPINE1;GADD45B;GADD45G;...
N-Glycan biosynthesis	1.64	3.84e-2	38/50 (76%)	ALG5;ST6GAL1;MAN1A1;...
Diabetic cardiomyopathy	1.62	4.89e-2	162/203 (79.8%)	PDK4;COX5B;NDUFA6;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H