Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2OGZ5)

• Drug Name: MORIN Drug Info
• Synonyms: morin; 480-16-0; Aurantica; Calico Yellow; Al-Morin; Toxylon Pomiferum; Morin hydrate; 2',3,4',5,7-Pentahydroxyflavone; 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one; Bois d,Arc; Osage Orange; Osage Orange Extract; Bois d'arc; C.I. Natural Yellow 11; C.I. Natural Yellow 8; Osage Orange Crystals; 3,5,7,2',4'-Pentahydroxyflavone; 3,5,7,2',4'-Pentahydroxyflavonol; 2'-Hydroxypelargidenolon 1522; 2',4',3,5,7-Pentahydroxyflavone; C.I. 75660; Zlut prirodni 11; 2',4',5,7-Tetrahydroxyflavan-3-ol; Bois d'arc [French]
• Cross-matching ID:
  PubChem CID: 5281670
  ChEBI ID: CHEMBL28626
  CAS Number: CAS 480-16-0
  TTD Drug ID: D0NJ4H
  VARIDT Drug ID: DR00652

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.19	0.00e+0	34/36 (94.44%)	RPA3;PRIM1;MCM4;...
Homologous recombination	1.84	4.69e-2	35/41 (85.37%)	RPA3;RBBP8;BRCA1;...
RNA degradation	1.82	4.54e-2	53/79 (67.09%)	PAN2;LSM5;LSM7;...
ABC transporters	-1.78	3.40e-2	37/45 (82.22%)	ABCD1;ABCB4;ABCA2;...
Legionellosis	-1.84	2.72e-2	51/57 (89.47%)	HSPD1;TNF;CXCL1;...
Protein processing in endoplasmic reticulum	-1.88	2.55e-2	127/171 (74.27%)	SAR1A;HSPBP1;EIF2AK2;...
Mitophagy	-1.90	3.40e-2	56/68 (82.35%)	NBR1;ATG9A;AMBRA1;...
Retinol metabolism	-1.99	5.67e-3	41/68 (60.29%)	CYP2B6;BCO1;ADH1C;...
Steroid hormone biosynthesis	-2.29	0.00e+0	43/61 (70.49%)	CYP21A2;CYP3A4;SULT1E1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.2uM - 25uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.2uM - 25uM	6H, 24H	Hide ▲