Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2OVDT)

• Drug Name: TECFIDERA Drug Info
• Synonyms: DIMETHYL FUMARATE
• Cross-matching ID:
  PubChem CID: 637568
  ChEBI ID: CHEMBL2107333
  CAS Number: CAS 624-49-7
  TTD Drug ID: D0A7MY
  ACDINA Drug ID: D00202

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ribosome biogenesis in eukaryotes	1.94	8.68e-3	52/108 (48.15%)	NOP56;NVL;POP5;...
One carbon pool by folate	1.80	2.60e-2	15/20 (75%)	TYMS;MTHFD1;SHMT2;...
Base excision repair	1.79	2.02e-2	29/33 (87.88%)	PCNA;FEN1;APEX1;...
Oxidative phosphorylation	-1.88	1.85e-2	93/133 (69.92%)	ATP6V0A4;ATP6V1A;COX8A;...
Steroid biosynthesis	-1.94	0.00e+0	19/20 (95%)	HSD17B7;LSS;CYP24A1;...
Mineral absorption	-2.13	0.00e+0	48/60 (80%)	ATP1A1;SLC26A3;CYBRD1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼