Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2OZ3G)

Drug Name
Ixabepilone Drug Info
Synonyms Azaepothilone B; BMS-247550; Ixempra (TN)
Cross-matching ID
PubChem CID
6445540
ChEBI ID
CHEMBL63605
CAS Number
CAS 219989-84-1
TTD Drug ID
D0W2EK
VARIDT Drug ID
DR01285
INTEDE Drug ID
DR0900
ACDINA Drug ID
D01188

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 1.80 4.86e-2 52/108 (48.15%) REXO2;NXF3;DKC1;...
Glyoxylate and dicarboxylate metabolism -1.74 3.23e-2 23/30 (76.67%) MDH2;SHMT2;PCCB;...
Protein processing in endoplasmic reticulum -1.76 2.84e-2 127/171 (74.27%) MAN1A2;OS9;CKAP4;...
Glutathione metabolism -1.81 1.53e-2 43/57 (75.44%) GSTK1;GSTM3;GPX2;...
Glycolysis / Gluconeogenesis -1.82 1.59e-2 56/67 (83.58%) ADH1C;DLD;FBP1;...
Pentose and glucuronate interconversions -1.86 7.42e-3 17/34 (50%) AKR1B1;GUSB;UGT2A3;...
Mismatch repair -1.86 8.90e-3 22/23 (95.65%) MSH2;POLD1;MSH3;...
Drug metabolism -1.87 1.11e-2 78/151 (51.66%) TYMP;GSTM2;GUSB;...
Ascorbate and aldarate metabolism -1.91 7.42e-3 15/30 (50%) GUSB;UGT2A3;RGN;...
DNA replication -2.09 0.00e+0 34/36 (94.44%) RNASEH2A;LIG1;DNA2;...
Metabolism of xenobiotics by cytochrome P450 -2.10 0.00e+0 49/77 (63.64%) SULT2A1;CYP2D6;UGT2B4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H