Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2POTE)

• Drug Name: Colchicine Drug Info
• Synonyms: Colchicin; Colchicina; Colchicinum; Colchineos; Colchisol; Colchysat; Colcin; Colcrys; Colsaloid; Colstat; Condylon; Goutnil; Kolkicin; LOC; Binds to tubulin; Colchicin [German]; Colchicina [Italian]; Colchicine [JAN]; Inhibits microtubular assembly; Spindle poison; C 9754; Colchicine (TN); Colchicine, Colchicum autumnale; MPC-004; N-Acetyl trimethylcolchicinic acid methylether; Colchicine (JP15/USP); Colchicine, (R)-Isomer; Benzo(a)heptalen-9(5H)-one; Colchicine, (+-)-Isomer; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide; N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide; N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide; N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[.alpha.]heptalen-7-yl)-acetamide; N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-acetamide; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; 7-alpha-H-Colchicine; 7.alpha.H-Colchicine; 7alphaH-Colchicine
• Therapeutic Class: Gout Suppressants
• Cross-matching ID:
  PubChem CID: 6167
  ChEBI ID: CHEMBL107
  CAS Number: CAS 64-86-8
  TTD Drug ID: D09DHY
  VARIDT Drug ID: DR00135
  INTEDE Drug ID: DR0372
  ACDINA Drug ID: D00149

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Focal adhesion	2.26	0.00e+0	180/201 (89.55%)	ITGA6;CAV1;SPP1;...
Hypertrophic cardiomyopathy	2.04	0.00e+0	81/90 (90%)	ITGA6;TPM1;TPM4;...
ECM-receptor interaction	2.03	0.00e+0	80/88 (90.91%)	ITGA6;SPP1;ITGA5;...
Bacterial invasion of epithelial cells	2.01	0.00e+0	59/77 (76.62%)	CAV1;ILK;CAV2;...
Dilated cardiomyopathy	1.94	0.00e+0	86/96 (89.58%)	ITGA6;TPM1;TPM4;...
Renal cell carcinoma	1.92	0.00e+0	68/69 (98.55%)	HRAS;AKT1;ELOC;...
Amoebiasis	1.88	7.19e-3	99/102 (97.06%)	ACTN1;CXCL3;ACTN4;...
ErbB signaling pathway	1.85	9.44e-3	79/85 (92.94%)	HBEGF;HRAS;AKT1;...
Proteoglycans in cancer	1.84	1.12e-2	172/205 (83.9%)	CAV1;CAV2;ITGA5;...
Salmonella infection	1.84	1.01e-2	198/249 (79.52%)	PODXL;S100A10;FLNA;...
Regulation of lipolysis in adipocytes	1.83	1.03e-2	52/55 (94.55%)	MGLL;AKT1;GNAI1;...
Mineral absorption	1.81	1.05e-2	48/60 (80%)	MT1E;MT1H;MT1G;...
Regulation of actin cytoskeleton	1.79	1.45e-2	185/218 (84.86%)	ITGA6;ACTN1;ITGA5;...
Hippo signaling pathway	1.78	1.44e-2	120/186 (64.52%)	CCN2;DVL1;TP53BP2;...
Arrhythmogenic right ventricular cardiomyopathy	1.75	1.68e-2	70/77 (90.91%)	ITGA6;ITGA5;DES;...
Small cell lung cancer	1.67	4.25e-2	90/92 (97.83%)	ITGA6;LAMC2;COL4A6;...
Lysine degradation	-1.57	3.33e-2	51/63 (80.95%)	COLGALT2;KMT2A;ACAT1;...
Butanoate metabolism	-1.59	3.05e-2	23/28 (82.14%)	ACAT1;HMGCL;ACADS;...
Sulfur metabolism	-1.62	2.38e-2	9/10 (90%)	PAPSS2;SUOX;SELENBP1
Nucleotide excision repair	-1.66	1.53e-2	40/47 (85.11%)	RFC3;DDB2;GTF2H3;...
Folate biosynthesis	-1.66	1.59e-2	23/26 (88.46%)	ALPL;GCH1;AKR1B1;...
beta-Alanine metabolism	-1.67	1.62e-2	25/30 (83.33%)	EHHADH;ALDH9A1;DPYD;...
Alanine, aspartate and glutamate metabolism	-1.67	1.56e-2	27/37 (72.97%)	PPAT;GAD2;ALDH4A1;...
Phenylalanine metabolism	-1.71	1.27e-2	14/17 (82.35%)	MAOB;MAOA;HPD;...
Tryptophan metabolism	-1.71	1.16e-2	35/42 (83.33%)	ACAT1;DLD;KYNU;...
Fanconi anemia pathway	-1.72	1.14e-2	36/54 (66.67%)	REV1;FANCA;FANCC;...
Primary bile acid biosynthesis	-1.73	1.12e-2	15/17 (88.24%)	CYP39A1;AKR1C4;ACOT8;...
Antigen processing and presentation	-1.76	7.50e-3	60/78 (76.92%)	HLA-DPA1;KLRC3;HLA-G;...
Pyruvate metabolism	-1.78	5.83e-3	41/47 (87.23%)	MDH2;ACAT2;PCK1;...
Nitrogen metabolism	-1.79	5.73e-3	16/17 (94.12%)	CA5A;GLUD2;CPS1;...
Glutathione metabolism	-1.80	6.09e-3	43/57 (75.44%)	MGST3;GSTA3;GPX3;...
Coronavirus disease	-1.82	6.00e-3	215/232 (92.67%)	MAPK14;RPS13;RPL37;...
Glycine, serine and threonine metabolism	-1.88	3.21e-3	31/40 (77.5%)	AGXT;CTH;GLDC;...
Glycolysis / Gluconeogenesis	-1.90	3.46e-3	56/67 (83.58%)	HK2;MINPP1;PCK2;...
Fatty acid degradation	-1.92	3.12e-3	40/43 (93.02%)	ADH1B;ACAA1;ACAA2;...
Tyrosine metabolism	-1.92	3.41e-3	30/36 (83.33%)	TYR;MAOB;DCT;...
One carbon pool by folate	-1.93	3.75e-3	15/20 (75%)	SHMT2;FTCD;MTHFS;...
Peroxisome	-1.94	4.16e-3	72/82 (87.8%)	ACOT8;ACSL5;AGXT;...
Ascorbate and aldarate metabolism	-1.96	2.81e-3	15/30 (50%)	ALDH2;RGN;UGDH;...
Pentose and glucuronate interconversions	-2.00	0.00e+0	17/34 (50%)	UGDH;UGP2;AKR1B1;...
Glyoxylate and dicarboxylate metabolism	-2.00	0.00e+0	23/30 (76.67%)	ACAT1;DLD;MDH2;...
Steroid hormone biosynthesis	-2.02	0.00e+0	43/61 (70.49%)	CYP17A1;CYP1A2;SULT1E1;...
Drug metabolism	-2.07	0.00e+0	78/151 (51.66%)	ADH6;MGST3;CYP1A2;...
Mismatch repair	-2.23	0.00e+0	22/23 (95.65%)	MSH3;POLD3;MLH1;...
Metabolism of xenobiotics by cytochrome P450	-2.29	0.00e+0	49/77 (63.64%)	GSTM1;CYP2A6;GSTM4;...
DNA replication	-2.38	0.00e+0	34/36 (94.44%)	RFC3;DNA2;MCM7;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.04uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼