Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2PW8T)

• Drug Name: [3H]7-OH-DPAT Drug Info
• Synonyms: 7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol; 7-OH-DPAT; 7-Ohdpat; DP-7-AT; 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol; 7-Hydroxy-N,N-di-n-propyl-2-aminotetralin; 7-Hydroxy-2-N,N-dipropylaminotetralin; N,N-Di-n-propyl-7-hydroxy-2-aminotetralin; CHEMBL285755; 7-(Dipropylamino)-5,6,7,8-tetrahydro-2-naphthalenol; 2-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-; 7-Hydroxy-DPAT hydrobromide; (+)-7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol hydrobromide; [3H]-7-OH-DPAT; (+)7-OH-DPAT; AC1Q7AGR; AC1L1AZK; [3H]-7-OH-DPAT; (+/-)-7-hydroxy-2-(N,N-di-n-propylamino)tetralin
• Cross-matching ID:
  PubChem CID: 1219
  ChEBI ID: CHEMBL111176
  CAS Number: CAS 74938-11-7
  TTD Drug ID: D03PYX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Nitrogen metabolism	-1.88	2.69e-2	16/17 (94.12%)	GLUL;CA12;CA2
Thyroid cancer	-1.93	1.34e-2	36/37 (97.3%)	CCND1;CCDC6;GADD45G;...
Bile secretion	-1.94	1.34e-2	68/90 (75.56%)	SLC4A4;ADCY7;ATP1B2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Bone marrow

Neuroblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SH-SY5Y	CVCL_0019	Homo sapiens	0.04uM - 10uM	24H	Hide ▲
SK-N-SH	CVCL_0531	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Show ▼