Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2PYNR)

• Drug Name: Phenindione Drug Info
• Synonyms: Athrombon; Bindan; Cronodione; Danedion; Danilon; Danilone; Diadilan; Dindevan; Dineval; Diophindane; Emandion; Emandione; Eridione; Fenhydren; Fenilin; Fenindion; Fenindiona; Hedulin; Hemolidione; Indema; Indion; Indon; Phenhydren; Phenillin; Phenindionum; Phenylen; Phenylin; Phenylindanedione; Phenylindione; Phenyline; Phenyllin; Pindione; Rectadione; Theradione; Thrombasal; Tromazal; Trombol; Boots Brand of Phenindione; Goldshield Brand of Phenindione; Merck Lipha Sante Brand of Phenindione; P1029; P26406_ALDRICH; Fenindiona [INN-Spanish]; Hedulin (TN); Phenindione (INN); Phenindione [INN:BAN]; Phenindionum [INN-Latin]; 2 Phenyl 1,3 indandione; 2-Fenyloindandion-1,3; 2-Fenyloindandion-1,3 [Polish]; 2-Phenyl-1,3-diketohydrindene; 2-Phenyl-1,3-indandione; 2-Phenyl-1,3-indanedione; 2-Phenyl-1H-indene-1,3(2H)-dione; 2-Phenylindan-1,3-dione; 2-Phenylindandione; 2-phenyl-1,3(2H)-Indenedione; 2-phenyl-2,3-dihydro-1H-indene-1,3-dione; 2-phenylindene-1,3-dione
• Therapeutic Class: Anticoagulants
• Cross-matching ID:
  PubChem CID: 4760
  ChEBI ID: CHEMBL8066
  CAS Number: CAS 83-12-5
  TTD Drug ID: D08FTG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Aminoacyl-tRNA biosynthesis	2.02	9.35e-3	15/66 (22.73%)	GATC;FARSA;NARS2;...
RNA polymerase	1.95	4.68e-3	23/31 (74.19%)	POLR2I;POLR2J;POLR3B;...
Base excision repair	1.81	2.49e-2	29/33 (87.88%)	HMGB1;FEN1;POLD2;...
Homologous recombination	1.79	2.57e-2	35/41 (85.37%)	RAD54B;SSBP1;RAD51C;...
Vitamin digestion and absorption	-1.78	4.41e-2	17/24 (70.83%)	APOA1;PNLIP;TCN2;...
Other glycan degradation	-1.89	1.84e-2	13/18 (72.22%)	NEU1;MAN2B2;GLB1;...
Protein digestion and absorption	-1.99	3.50e-3	78/103 (75.73%)	COL9A3;CPA1;CELA3B;...
ECM-receptor interaction	-2.20	0.00e+0	80/88 (90.91%)	TNN;GP1BA;ITGA10;...
Mineral absorption	-2.32	0.00e+0	48/60 (80%)	VDR;S100G;TRPV6;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲