Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2Q50G)

Drug Name
Belnacasan Drug Info
Synonyms Second generation ICE inhibitors, Vertex; VRT-043198; VRT-43198; VX-765; VX-765)
Cross-matching ID
PubChem CID
11398092
CAS Number
CAS 273404-37-8
TTD Drug ID
D0HK3N

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycolysis / Gluconeogenesis 2.00 1.37e-2 56/67 (83.58%) PKM;GAPDH;GPI;...
Pentose and glucuronate interconversions -1.73 1.92e-2 17/34 (50%) CRYL1;UGT2B17;UGT2B4;...
Histidine metabolism -1.76 1.74e-2 16/22 (72.73%) ALDH9A1;ALDH3B1;ALDH2;...
Arachidonic acid metabolism -1.80 1.42e-2 48/61 (78.69%) HPGDS;ALOX12;CYP4F3;...
Linoleic acid metabolism -1.80 1.55e-2 21/29 (72.41%) CYP2E1;CYP2C9;CYP3A4;...
Drug metabolism -1.81 1.73e-2 78/151 (51.66%) MGST2;GSTM4;ADH1A;...
Alanine, aspartate and glutamate metabolism -1.86 1.16e-2 27/37 (72.97%) ALDH4A1;NIT2;GLUL;...
Arginine biosynthesis -1.88 1.11e-2 17/22 (77.27%) GLUL;GLUD1;OTC;...
Metabolism of xenobiotics by cytochrome P450 -2.02 0.00e+0 49/77 (63.64%) AKR1C1;ALDH3B1;GSTO1;...
Retinol metabolism -2.18 0.00e+0 41/68 (60.29%) ADH1A;DGAT1;ALDH1A3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H