Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2QJKZ)

Drug Name
SB 258585 Drug Info
Synonyms
SB-258585; SB258585; SB-258,585; Tocris-1961; NCGC00025328-01; AC1MN2NM; SCHEMBL678180; CHEMBL60264; GTPL3232; CHEBI:93418; BDBM86428; ZINC3923836; NCGC00025328-02; BRD-K80639402-003-01-1; 4-iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamide; 4-iodo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]benzenesulfonamide; Benzenesulfonamide, 4-iodo-N-(4-methoxy-3-(4-methyl-1-piperazinyl)phenyl)-
Cross-matching ID
PubChem CID
3248571
ChEBI ID
CHEMBL93418
CAS Number
CAS 209480-63-7
TTD Drug ID
D0L7PA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cardiac muscle contraction -1.78 4.78e-2 64/87 (73.56%) TNNT2;CACNA2D1;SLC8A1;...
Pertussis -1.92 1.16e-2 64/76 (84.21%) IL12B;JUN;RELA;...
Leishmaniasis -1.92 1.36e-2 67/77 (87.01%) MYD88;FCGR2C;EEF1A2;...
Complement and coagulation cascades -1.94 1.40e-2 76/85 (89.41%) SERPINA5;F10;F5;...
Neutrophil extracellular trap formation -1.98 8.72e-3 101/189 (53.44%) GP1BA;ITGAL;CLCN4;...
Legionellosis -2.03 7.76e-3 51/57 (89.47%) ARF1;MYD88;EEF1A2;...
Systemic lupus erythematosus -2.11 5.82e-3 45/135 (33.33%) HLA-DPA1;C1S;C3;...
Staphylococcus aureus infection -2.13 1.16e-2 72/95 (75.79%) FCGR2C;SELP;HLA-DPA1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H