Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2T5OV)

Drug Name
DC-EBIO Drug Info
Synonyms dichloro-EBIO
Cross-matching ID
PubChem CID
656765
ChEBI ID
CHEMBL34662
CAS Number
CAS 60563-36-2
TTD Drug ID
D0I6MA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 1.98 0.00e+0 52/108 (48.15%) NVL;DKC1;RRP7A;...
Mineral absorption 1.80 4.72e-2 48/60 (80%) SLC26A3;MT1E;SLC34A2;...
Glycosaminoglycan degradation -1.70 4.89e-2 19/19 (100%) HPSE2;SGSH;ARSB;...
Antigen processing and presentation -1.72 4.51e-2 60/78 (76.92%) CANX;KLRD1;CREB1;...
Legionellosis -1.74 4.42e-2 51/57 (89.47%) CASP3;HSPA1A;CASP7;...
Fluid shear stress and atherosclerosis -1.74 4.75e-2 123/139 (88.49%) SDC1;VCAM1;TNFRSF1A;...
Pertussis -1.79 2.95e-2 64/76 (84.21%) CALML5;ITGB1;IL1A;...
Phagosome -1.82 1.87e-2 118/152 (77.63%) FCGR2B;RAB7A;LAMP2;...
Malaria -1.85 2.08e-2 44/50 (88%) ITGAL;CCL2;TGFB3;...
Lysosome -1.94 1.04e-2 115/128 (89.84%) MANBA;ATP6V0A1;HYAL2;...
Steroid biosynthesis -1.95 1.04e-2 19/20 (95%) SOAT2;TM7SF2;DHCR7;...
Rheumatoid arthritis -2.00 1.04e-2 78/93 (83.87%) TGFB1;ATP6V1C1;ANGPT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H