Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2TEOL)

Drug Name
Methotrexate Drug Info
Synonyms
methotrexate; 1959/5/2; Rheumatrex; Amethopterin; Metatrexan; Hdmtx; Abitrexate; Mexate; Methylaminopterinum; Methotrexatum; Antifolan; Metotrexato; Methylaminopterin; MTX; (S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid; Methotrexat; Amethopterine; Maxtrex; Rasuvo; L-Amethopterin; A-Methopterin; A-Methpterin; Amethopterin L-; Folex-Pfs; Methotrexat-Ebewe; N-Bismethylpteroylglutamic acid; Methotrexate, L-; Metotressato [DCIT]; Methotextrate; Mexate-Aq; [3H]methotrexate
Cross-matching ID
PubChem CID
126941
ChEBI ID
CHEMBL34259
CAS Number
CAS 59-05-2
TTD Drug ID
D0SV8E
VARIDT Drug ID
DR00082
INTEDE Drug ID
DR1045
ACDINA Drug ID
D00412

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
p53 signaling pathway 2.29 0.00e+0 63/73 (86.3%) SERPINE1;DDB2;FAS;...
DNA replication 2.06 0.00e+0 34/36 (94.44%) LIG1;MCM5;PCNA;...
One carbon pool by folate 2.06 0.00e+0 15/20 (75%) TYMS;MTHFD1;DHFR;...
Drug metabolism 2.04 0.00e+0 78/151 (51.66%) RRM2;DUT;ADH1B;...
Mismatch repair 1.97 6.49e-3 22/23 (95.65%) LIG1;PCNA;RFC4;...
Viral myocarditis 1.92 7.22e-3 53/60 (88.33%) CAV1;ICAM1;HLA-B;...
Complement and coagulation cascades 1.91 6.18e-3 76/85 (89.41%) SERPINE1;CFI;PLAU;...
Nucleotide excision repair 1.91 5.41e-3 40/47 (85.11%) DDB2;LIG1;PCNA;...
Graft-versus-host disease 1.89 4.81e-3 32/42 (76.19%) FAS;HLA-B;HLA-F;...
Pyrimidine metabolism 1.89 4.33e-3 40/56 (71.43%) TYMS;RRM2;DCK;...
Glutathione metabolism 1.88 4.92e-3 43/57 (75.44%) GPX1;RRM2;IDH2;...
ECM-receptor interaction 1.88 4.51e-3 80/88 (90.91%) THBS2;COL6A1;ITGB4;...
Malaria 1.84 5.00e-3 44/50 (88%) THBS2;CXCL8;VCAM1;...
Sulfur metabolism 1.83 5.41e-3 9/10 (90%) ETHE1;SQOR;TST;...
Base excision repair 1.81 7.22e-3 29/33 (87.88%) LIG1;PCNA;APEX1;...
Allograft rejection 1.80 8.79e-3 32/38 (84.21%) FAS;HLA-B;HLA-F;...
Apoptosis 1.79 8.28e-3 126/168 (75%) TNFSF10;FAS;GADD45A;...
Retinol metabolism 1.75 1.50e-2 41/68 (60.29%) ALDH1A3;ALDH1A1;ADH1B;...
Riboflavin metabolism 1.75 1.48e-2 7/8 (87.5%) ENPP1;ACP1
Small cell lung cancer 1.72 1.79e-2 90/92 (97.83%) DDB2;CDKN1A;GADD45A;...
TNF signaling pathway 1.71 2.01e-2 103/112 (91.96%) FAS;VCAM1;EDN1;...
African trypanosomiasis 1.71 1.92e-2 32/37 (86.49%) F2RL1;FAS;VCAM1;...
Linoleic acid metabolism 1.68 3.06e-2 21/29 (72.41%) PLAAT3;CYP2E1;CYP2J2;...
Ribosome 1.67 3.02e-2 113/158 (71.52%) RPS4Y1;RPS27L;RPL10;...
NF-kappa B signaling pathway 1.66 3.46e-2 90/104 (86.54%) CXCL8;VCAM1;PLAU;...
Metabolism of xenobiotics by cytochrome P450 1.65 3.46e-2 49/77 (63.64%) AKR7A2;ADH1B;GSTK1;...
Melanoma 1.65 3.65e-2 68/72 (94.44%) DDB2;CDKN1A;GADD45A;...
Fatty acid degradation 1.63 4.14e-2 40/43 (93.02%) ACADVL;ADH1B;ALDH2;...
Nicotine addiction -1.74 4.46e-2 32/40 (80%) GABRB1;GABRA4;GRIA1;...
Protein processing in endoplasmic reticulum -1.83 2.08e-2 127/171 (74.27%) PDIA4;NPLOC4;HSPA2;...
GABAergic synapse -1.87 5.35e-3 76/89 (85.39%) GABRB1;ADCY7;GABBR1;...
Spliceosome -1.95 2.23e-3 101/150 (67.33%) SF3A3;SNW1;HSPA2;...
Progesterone-mediated oocyte maturation -1.96 2.97e-3 75/100 (75%) CDC27;AKT3;ADCY8;...
mRNA surveillance pathway -2.12 0.00e+0 71/98 (72.45%) PABPC3;PAPOLB;NXF3;...
Steroid biosynthesis -2.18 0.00e+0 19/20 (95%) HSD17B7;SOAT1;EBP;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.37uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.66uM - 20uM 3H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H