Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2TUCU)

Drug Name
Crotamiton Drug Info
Synonyms
crotamiton; 483-63-6; N-Ethyl-o-crotonotoluidide; Crotamitone; Crotalgin; Eurax; Veteusan; Euraxil; Eurasil; trans-Crotamiton; Crotamitonum; Crotamitex; Crotan; Crotonyl-N-ethyl-o-toluidine; 124236-29-9; Caswell No. 431B; Crotamitonum [INN-Latin]; UNII-2EEH27851Y; o-CROTONOTOLUIDIDE, N-ETHYL-; EINECS 207-596-3; EPA Pesticide Chemical Code 055701; BRN 3275497; (E)-N-Ethyl-N-(o-tolyl)but-2-enamide; N-Ethyl-N-(2-methylphenyl)-2-butenamide; AI3-17732; DNTGGZPQPQTDQF-XBXARRHUSA-N; 2-Butenamide, N-ethyl-N-(2-methylphenyl)-; 2EEH27851Y
Cross-matching ID
PubChem CID
688020
ChEBI ID
CHEMBL31439
CAS Number
CAS 124236-29-9
TTD Drug ID
D0T3NY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway -1.76 4.21e-2 84/94 (89.36%) TRAF3IP2;NFKB1;IL5;...
Mitophagy -1.76 4.81e-2 56/68 (82.35%) TBC1D15;EIF2AK3;MAPK10;...
Collecting duct acid secretion -2.04 0.00e+0 22/27 (81.48%) ATP6V0C;ATP6V0A4;ATP6V1A;...
TNF signaling pathway -2.12 0.00e+0 103/112 (91.96%) IRF1;MAP2K4;NFKB1;...
Mucin type O-glycan biosynthesis -2.14 0.00e+0 20/36 (55.56%) GALNT1;GALNT14;GALNT7;...
Rheumatoid arthritis -2.26 0.00e+0 78/93 (83.87%) ATP6V0D1;FLT1;TGFB2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 15uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H