Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2UZL9)

• Drug Name: Bufexamac Drug Info
• Synonyms: bufexamac; 2438-72-4; Bufexamic acid; 2-(4-Butoxyphenyl)-N-hydroxyacetamide; Parfenac; Parfenal; Feximac; Mofenar; Malipuran; Droxaryl; Bufexamacum; Flogicid; Bufexamaco; Paraderm; Norfemac; Anderm; 4-Butoxy-N-hydroxybenzeneacetamide; p-Butoxyphenylacetohydroxamic acid; 4-Butoxyphenylacetohydroxamic acid; Flogocid N plastigel; Acide p-butoxyphenylacethydroxamique; 2-(p-Butoxyphenyl)-acetohydroxamic acid; Bufessamac [DCIT]; Bufexamacum [INN-Latin]; Bufexamaco [INN-Spanish]; CP 1044 J3; UNII-4T3C38J78L; Benzeneacetamide, 4-butoxy-N-hyd
• Cross-matching ID:
  PubChem CID: 2466
  ChEBI ID: CHEMBL94394
  CAS Number: CAS 2438-72-4
  TTD Drug ID: D02HXS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Galactose metabolism	1.86	3.63e-2	26/31 (83.87%)	PFKP;AKR1B1;AKR1B10;...
Lysosome	1.84	3.94e-2	115/128 (89.84%)	CTSH;LAPTM5;PSAP;...
Glycolysis / Gluconeogenesis	1.83	3.15e-2	56/67 (83.58%)	PKM;ADH5;PFKP;...
Cell adhesion molecules	1.82	3.23e-2	118/148 (79.73%)	HLA-B;NRCAM;ALCAM;...
Terpenoid backbone biosynthesis	1.82	2.94e-2	18/22 (81.82%)	ACAT2;IDI1;PCYOX1;...
Fructose and mannose metabolism	1.78	3.63e-2	30/33 (90.91%)	PFKP;AKR1B1;PFKFB3;...
Propanoate metabolism	1.77	3.90e-2	30/34 (88.24%)	ACAT2;SUCLG2;HIBCH;...
Shigellosis	1.76	3.88e-2	180/246 (73.17%)	CRK;TLR4;PFN2;...
HIF-1 signaling pathway	1.74	4.07e-2	105/109 (96.33%)	TLR4;PFKP;ERBB2;...
Bacterial invasion of epithelial cells	1.72	4.54e-2	59/77 (76.62%)	CRK;CDH1;ITGB1;...
Mismatch repair	-1.70	3.48e-2	22/23 (95.65%)	EXO1;MLH1;RFC5;...
Mineral absorption	-1.74	2.71e-2	48/60 (80%)	FTH1;MT2A;TF;...
Base excision repair	-1.87	7.47e-3	29/33 (87.88%)	PARP1;MUTYH;POLB;...
Taurine and hypotaurine metabolism	-1.89	6.22e-3	8/11 (72.73%)	GGT1;GAD2;CSAD;...
Fanconi anemia pathway	-1.89	4.48e-3	36/54 (66.67%)	ERCC1;FAN1;RPA3;...
Complement and coagulation cascades	-1.92	3.73e-3	76/85 (89.41%)	C1QB;F5;PLAUR;...
Staphylococcus aureus infection	-1.97	2.49e-3	72/95 (75.79%)	C1QB;FCGR2A;HLA-DMB;...
Cell cycle	-2.09	0.00e+0	110/124 (88.71%)	PKMYT1;TTK;MCM6;...
DNA replication	-2.27	0.00e+0	34/36 (94.44%)	POLD1;MCM6;DNA2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	24H	Hide ▲