Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2XC05)

Drug Name
Latrunculin B Drug Info
Synonyms INS-115644; Cytoskeleton-targeting compounds (glaucoma), Wisconsin Alumni Research Foundation (WARF)/Inspire
Cross-matching ID
PubChem CID
6436219
ChEBI ID
CHEMBL49703
CAS Number
CAS 76343-94-7
TTD Drug ID
D07EHB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Lysosome 2.38 0.00e+0 115/128 (89.84%) CTSK;CTSA;TPP1;...
ABC transporters 2.12 0.00e+0 37/45 (82.22%) ABCA8;TAP1;ABCG1;...
Inositol phosphate metabolism 2.10 0.00e+0 66/73 (90.41%) CDIPT;MINPP1;PLCB1;...
Phosphatidylinositol signaling system 2.07 0.00e+0 82/97 (84.54%) PRKCA;CDIPT;PLCB1;...
Regulation of lipolysis in adipocytes 1.97 0.00e+0 52/55 (94.55%) FABP4;IRS2;ADCY9;...
Aldosterone-regulated sodium reabsorption 1.89 1.01e-2 34/37 (91.89%) PRKCA;SCNN1A;SGK1;...
Other glycan degradation 1.83 1.73e-2 13/18 (72.22%) NEU1;HEXB;ENGASE;...
Mucin type O-glycan biosynthesis 1.81 1.66e-2 20/36 (55.56%) B4GALT5;GCNT3;GALNT12;...
Notch signaling pathway 1.78 2.28e-2 49/59 (83.05%) TLE1;ATXN1;RBPJ;...
Collecting duct acid secretion 1.75 2.78e-2 22/27 (81.48%) ATP6V0E1;ATP6V1A;SLC12A7;...
Sulfur metabolism 1.73 3.30e-2 9/10 (90%) SELENBP1;TST;SUOX;...
RNA polymerase -1.64 4.18e-2 23/31 (74.19%) POLR2E;POLR2H;POLR2F;...
Glycine, serine and threonine metabolism -1.65 4.22e-2 31/40 (77.5%) PGAM1;DAO;PIPOX;...
Homologous recombination -1.65 4.37e-2 35/41 (85.37%) BRIP1;BRCA2;BRCA1;...
RNA degradation -1.68 3.82e-2 53/79 (67.09%) PFKP;EDC3;LSM7;...
Base excision repair -1.69 3.84e-2 29/33 (87.88%) HMGB1;LIG1;PCNA;...
Fanconi anemia pathway -1.71 3.66e-2 36/54 (66.67%) ERCC4;FANCC;RMI1;...
Mismatch repair -1.81 1.73e-2 22/23 (95.65%) MSH2;POLD3;POLD1;...
Pyrimidine metabolism -1.86 1.20e-2 40/56 (71.43%) CMPK1;CAD;DCTPP1;...
Proteasome -1.86 1.26e-2 44/46 (95.65%) ADRM1;PSMB4;IFNG;...
Nucleotide excision repair -1.90 1.13e-2 40/47 (85.11%) POLD1;RFC5;RAD23A;...
Spliceosome -1.91 8.40e-3 101/150 (67.33%) PRPF19;SNU13;PCBP1;...
Cell cycle -1.92 1.01e-2 110/124 (88.71%) TP53;E2F1;CCNE2;...
Ribosome biogenesis in eukaryotes -1.97 7.20e-3 52/108 (48.15%) NAT10;SNU13;RBM28;...
RNA transport -1.99 7.20e-3 128/186 (68.82%) THOC1;SEH1L;POP5;...
Ribosome -2.42 0.00e+0 113/158 (71.52%) RPL10A;RPS3;RPS25;...
DNA replication -2.53 0.00e+0 34/36 (94.44%) MCM6;MCM2;LIG1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 20uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.25uM - 12.5uM 3H, 6H, 12H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H