Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM2Y0AI)

Drug Name
Diminazene Drug Info
Synonyms
DIMINAZENE; 536-71-0; berenil; Diminazenum; Diminazeno; Diminazine; Azidin; Pirocide; Diminazene [INN:BAN]; Diminazenum [INN-Latin]; Diminazeno [INN-Spanish]; UNII-Y5G36EEA5Z; 4,4'-(Diazoamino)benzamidine; CHEBI:81724; 4,4'-(1-Triazene-1,3-diyl)bis-benzenecarboximidamide; Benzenecarboximidamide, 4,4'-(1-triazene-1,3-diyl)bis-; EINECS 208-644-6; Y5G36EEA5Z; C14H15N7; Bevenil; 1,3-TRIS-(4'AMIDINOPHENYL)TRIAZINE; 4,4'-(Triaz-1-ene-1,3-diyl)dibenzimidamide; 4,4'-(1-Triazene-1,3-diyl)bisbenzenecarboximidamide
Cross-matching ID
PubChem CID
2354
ChEBI ID
CHEMBL35241
CAS Number
CAS 536-71-0
TTD Drug ID
D0B8TJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.02 1.71e-2 44/46 (95.65%) PSMD12;PSMD11;PSMB3;...
Cell cycle 1.96 2.14e-2 110/124 (88.71%) CHEK1;CDC20;CCND2;...
Porphyrin and chlorophyll metabolism 1.84 3.42e-2 23/43 (53.49%) PPOX;HEPH;CPOX;...
Nicotine addiction 1.84 2.57e-2 32/40 (80%) GRIA2;SLC17A7;GABRB1;...
Cholesterol metabolism -1.62 4.84e-2 44/50 (88%) CETP;LDLRAP1;PLTP;...
Shigellosis -1.63 4.85e-2 180/246 (73.17%) TLR5;ILK;SHARPIN;...
Malaria -1.64 4.75e-2 44/50 (88%) CCL2;CD36;HGF;...
IL-17 signaling pathway -1.64 4.93e-2 84/94 (89.36%) FOSB;CCL7;MMP1;...
Arachidonic acid metabolism -1.67 3.31e-2 48/61 (78.69%) PTGS1;PLA2G2D;PTGS2;...
Endocrine and other factor-regulated calcium reabsorpti... -1.69 2.50e-2 49/53 (92.45%) PRKACA;PLCB1;FXYD2;...
Leishmaniasis -1.73 1.65e-2 67/77 (87.01%) C3;NCF2;IL1A;...
Epithelial cell signaling in Helicobacter pylori infect... -1.79 1.15e-2 62/70 (88.57%) CXCR2;ATP6V1B1;CDC42;...
Glycosaminoglycan biosynthesis -1.79 1.23e-2 40/58 (68.97%) CHST15;EXT1;B3GAT3;...
Pertussis -1.80 1.32e-2 64/76 (84.21%) C3;GNAI2;IL1A;...
Salivary secretion -1.81 1.24e-2 76/93 (81.72%) KCNN4;PRB1;PLCB4;...
Steroid biosynthesis -1.82 1.25e-2 19/20 (95%) MSMO1;CYP27B1;CYP51A1;...
Lipid and atherosclerosis -1.83 1.15e-2 190/215 (88.37%) TNFRSF10B;PLCB4;IRAK4;...
Rheumatoid arthritis -1.85 1.15e-2 78/93 (83.87%) TGFB3;MMP1;FOS;...
Osteoclast differentiation -1.86 1.15e-2 117/127 (92.13%) TGFBR1;MAPK13;FCGR3B;...
Amoebiasis -1.93 4.91e-3 99/102 (97.06%) PLCB4;TGFB3;RAB5C;...
Complement and coagulation cascades -1.96 1.91e-3 76/85 (89.41%) CD59;MBL2;C3;...
African trypanosomiasis -1.96 2.29e-3 32/37 (86.49%) FAS;MYD88;PLCB1;...
Chagas disease -1.97 2.87e-3 93/102 (91.18%) C3;AKT2;GNAI2;...
TNF signaling pathway -1.97 3.82e-3 103/112 (91.96%) FOS;TRADD;CCL2;...
Legionellosis -2.14 0.00e+0 51/57 (89.47%) TLR2;RELA;CR1;...
NF-kappa B signaling pathway -2.28 0.00e+0 90/104 (86.54%) TICAM1;ZAP70;NFKBIA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H