Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM31ZQM)

Drug Name
Tegafur Drug Info
Synonyms Tegafur (Fluoropyrimidine)
Cross-matching ID
PubChem CID
5386
ChEBI ID
CHEMBL32188
CAS Number
CAS 17902-23-7
TTD Drug ID
D0F3SY
INTEDE Drug ID
DR1539

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.14 0.00e+0 34/36 (94.44%) PCNA;RPA3;RFC2;...
Oxidative phosphorylation 1.91 1.96e-2 93/133 (69.92%) COX7A1;COX7A2;NDUFA4;...
Folate biosynthesis 1.88 1.30e-2 23/26 (88.46%) DHFR;AKR1C3;GGH;...
Base excision repair 1.87 1.57e-2 29/33 (87.88%) PCNA;POLE2;FEN1;...
Mismatch repair 1.81 2.35e-2 22/23 (95.65%) PCNA;RPA3;RFC2;...
Legionellosis 1.79 2.61e-2 51/57 (89.47%) EEF1A2;HSPA8;CXCL8;...
Cardiac muscle contraction 1.78 2.46e-2 64/87 (73.56%) COX7A1;ATP1A2;COX7A2;...
Pyrimidine metabolism 1.75 2.94e-2 40/56 (71.43%) TYMS;DCK;NME4;...
Ribosome 1.75 2.61e-2 113/158 (71.52%) RPS4Y1;RPS27L;MRPS12;...
Viral myocarditis -1.76 4.98e-2 53/60 (88.33%) CAV1;CXADR;HLA-C;...
ECM-receptor interaction -1.76 4.81e-2 80/88 (90.91%) DAG1;COL4A3;LAMB2;...
Cortisol synthesis and secretion -1.81 3.85e-2 58/65 (89.23%) NR4A1;PDE8B;PDE8A;...
Allograft rejection -1.82 4.51e-2 32/38 (84.21%) HLA-F;IL5;HLA-E;...
Autoimmune thyroid disease -1.83 4.81e-2 46/53 (86.79%) CD28;HLA-G;HLA-DMB;...
Regulation of lipolysis in adipocytes -2.00 2.40e-2 52/55 (94.55%) IRS1;ADCY3;PTGER3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.66uM - 20uM 3H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 15uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H