Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM34J38)

• Drug Name: NanoDTPA Drug Info
• Cross-matching ID:
  PubChem CID: 3053
  TTD Drug ID: D0L6FF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Type I diabetes mellitus	1.91	4.02e-2	38/43 (88.37%)	CPE;TNF;HSPD1;...
Leukocyte transendothelial migration	1.90	3.35e-2	90/114 (78.95%)	CDC42;CLDN10;ITGAM;...
Natural killer cell mediated cytotoxicity	1.87	3.57e-2	99/131 (75.57%)	ITGB2;PRKCB;KRAS;...
Base excision repair	1.85	3.02e-2	29/33 (87.88%)	TDG;POLE2;NEIL3;...
Long-term potentiation	1.81	4.29e-2	61/67 (91.04%)	PLCB1;PRKCB;KRAS;...
Oxytocin signaling pathway	1.79	4.02e-2	128/154 (83.12%)	PLCB1;PTGS2;PRKAB1;...
Steroid hormone biosynthesis	-1.85	1.62e-2	43/61 (70.49%)	AKR1C2;AKR1D1;HSD3B2;...
Mineral absorption	-2.30	0.00e+0	48/60 (80%)	HMOX2;ATP1A1;SLC34A1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲