General Information of Drug (ID: DM367MF)

Drug Name
AC-7954 Drug Info
Synonyms AC7954; AC 7954
Cross-matching ID
PubChem CID
9797568
ChEBI ID
CHEMBL192359
TTD Drug ID
D0R8GW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Complement and coagulation cascades 2.71 0.00e+0 76/85 (89.41%) C4BPA;CFB;C7;...
Metabolism of xenobiotics by cytochrome P450 2.05 0.00e+0 49/77 (63.64%) ADH1B;GSTM3;ADH5;...
Staphylococcus aureus infection 1.86 1.58e-2 72/95 (75.79%) KRT23;CFB;CFH;...
Fatty acid degradation 1.82 2.14e-2 40/43 (93.02%) ACSL1;ADH1B;ADH5;...
Malaria 1.82 2.09e-2 44/50 (88%) HBB;THBS1;CCL2;...
Hypertrophic cardiomyopathy 1.78 3.17e-2 81/90 (90%) AGT;LAMA2;DAG1;...
Thermogenesis 1.73 4.07e-2 173/232 (74.57%) ACSL1;COX7A1;NDUFV2;...
Retinol metabolism 1.73 3.80e-2 41/68 (60.29%) ADH1B;ADH5;ADH1A;...
Drug metabolism 1.71 4.43e-2 78/151 (51.66%) ADH1B;GSTM3;ADH5;...
Oxidative phosphorylation 1.70 4.27e-2 93/133 (69.92%) COX7A1;NDUFV2;PPA1;...
Steroid hormone biosynthesis 1.70 3.97e-2 43/61 (70.49%) AKR1C2;CYP2E1;HSD17B2;...
Proteasome 1.69 4.12e-2 44/46 (95.65%) PSMA2;PSMC6;PSMA6;...
Pentose and glucuronate interconversions -1.71 3.56e-2 17/34 (50%) UGT2A3;AKR1A1;KL;...
Neomycin, kanamycin and gentamicin biosynthesis -1.72 3.77e-2 5/5 (100%) HK2;HK1
Protein processing in endoplasmic reticulum -1.81 1.05e-2 127/171 (74.27%) SEC23B;EDEM1;HSPA1L;...
Amino sugar and nucleotide sugar metabolism -1.86 6.33e-3 38/48 (79.17%) CYB5R2;PMM1;GMPPA;...
Fructose and mannose metabolism -1.96 0.00e+0 30/33 (90.91%) TPI1;PFKL;PMM1;...
Antigen processing and presentation -2.03 0.00e+0 60/78 (76.92%) TAPBP;TAP1;LGMN;...
Galactose metabolism -2.09 0.00e+0 26/31 (83.87%) HK2;HK1;AKR1B10;...
Asthma -2.13 0.00e+0 25/31 (80.65%) FCER1A;FCER1G;RNASE3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H