General Information of Drug (ID: DM36C17)

Drug Name
Blonanserin Drug Info
Synonyms
Lonasen; Blonanserin [INN]; AD 5423; AD-5423; Blonanserin (JAN/INN); 2-(4-Ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta(b)pyridine; 2-(4-Ethyl-1-piperazinyl)-4-(p-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta(b)pyridine; 2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
Cross-matching ID
PubChem CID
125564
ChEBI ID
CHEMBL178803
CAS Number
CAS 132810-10-7
TTD Drug ID
D08GJH
INTEDE Drug ID
DR1902

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Epstein-Barr virus infection 1.90 5.16e-2 189/202 (93.56%) ISG15;BTK;BLNK;...
Spliceosome 1.84 5.16e-2 101/150 (67.33%) THOC2;HNRNPM;RBM25;...
Herpes simplex virus 1 infection 1.80 6.19e-2 165/498 (33.13%) DDX58;OAS3;OAS2;...
B cell receptor signaling pathway 1.75 7.22e-2 71/81 (87.65%) PPP3CA;BTK;BLNK;...
Antigen processing and presentation 1.75 5.98e-2 60/78 (76.92%) TAP1;HLA-B;HSPA5;...
Kaposi sarcoma-associated herpesvirus infection 1.68 1.05e-1 172/193 (89.12%) PPP3CA;LEF1;E2F2;...
Primary immunodeficiency 1.67 9.43e-2 33/38 (86.84%) BTK;BLNK;TAP1;...
Prostate cancer 1.67 8.25e-2 93/97 (95.88%) LEF1;E2F2;CDKN1B;...
Sulfur metabolism 1.59 1.78e-1 9/10 (90%) PAPSS1;SELENBP1
Taurine and hypotaurine metabolism 1.56 2.01e-1 8/11 (72.73%) CSAD;GAD1;BAAT
Signaling pathways regulating pluripotency of stem cell... 1.55 2.20e-1 110/143 (76.92%) ID3;TBX3;SMAD3;...
Hepatitis C 1.54 2.06e-1 139/157 (88.54%) IFIT1;MX1;E2F2;...
RNA degradation 1.52 2.13e-1 53/79 (67.09%) CNOT4;PFKL;BTG3;...
RIG-I-like receptor signaling pathway 1.49 2.67e-1 64/70 (91.43%) ISG15;DDX58;IRF7;...
Influenza A 1.49 2.54e-1 156/172 (90.7%) MX1;DDX58;OAS3;...
Gastric acid secretion 1.48 2.52e-1 63/76 (82.89%) GNAS;EZR;PRKCB;...
Homologous recombination 1.46 2.77e-1 35/41 (85.37%) BARD1;RBBP8;NBN;...
MicroRNAs in cancer 1.45 2.90e-1 146/310 (47.1%) E2F2;EZR;CDKN1B;...
Hippo signaling pathway 1.44 2.88e-1 120/186 (64.52%) LEF1;DLG5;SMAD3;...
Leishmaniasis 1.44 2.77e-1 67/77 (87.01%) MARCKSL1;PRKCB;TAB2;...
Butanoate metabolism 1.42 3.09e-1 23/28 (82.14%) ALDH5A1;ACAT2;GAD1;...
Coronavirus disease 1.42 3.00e-1 215/232 (92.67%) ISG15;MX1;CFD;...
Human papillomavirus infection 1.41 3.12e-1 284/331 (85.8%) ISG15;MX1;GNAS;...
Breast cancer 1.40 3.22e-1 119/147 (80.95%) LEF1;E2F2;FZD10;...
Type I diabetes mellitus 1.39 3.22e-1 38/43 (88.37%) HLA-B;GAD1;HLA-DMB;...
Protein digestion and absorption 1.39 3.12e-1 78/103 (75.73%) COL5A2;COL7A1;SLC7A7;...
Phosphonate and phosphinate metabolism 1.39 3.03e-1 5/6 (83.33%) CHPT1;CEPT1
Wnt signaling pathway 1.38 3.03e-1 124/166 (74.7%) PPP3CA;LEF1;TBL1XR1;...
Hepatocellular carcinoma 1.38 2.94e-1 135/168 (80.36%) LEF1;E2F2;GSTM3;...
Allograft rejection 1.37 3.20e-1 32/38 (84.21%) HLA-B;HLA-DMB;HLA-E;...
Mitophagy -1.21 5.96e-1 56/68 (82.35%) MFN2;BNIP3;TBC1D17;...
Dopaminergic synapse -1.22 5.68e-1 115/132 (87.12%) CLOCK;DRD5;AKT2;...
Fatty acid elongation -1.23 5.72e-1 19/27 (70.37%) HACD1;ELOVL5;HSD17B12;...
cAMP signaling pathway -1.23 5.73e-1 188/216 (87.04%) AMH;PDE4C;HTR6;...
Colorectal cancer -1.24 5.71e-1 84/86 (97.67%) KRAS;MAPK10;AXIN1;...
Complement and coagulation cascades -1.26 5.12e-1 76/85 (89.41%) PROCR;C4BPB;MBL2;...
JAK-STAT signaling pathway -1.27 5.19e-1 146/162 (90.12%) AKT2;GHR;SOCS6;...
Galactose metabolism -1.27 5.38e-1 26/31 (83.87%) PFKM;GCK;GALE;...
Parkinson disease -1.27 5.49e-1 176/249 (70.68%) PSMD6;CYC1;BAX;...
Citrate cycle (TCA cycle) -1.27 5.65e-1 30/30 (100%) MDH1;SDHC;OGDH;...
Hematopoietic cell lineage -1.27 5.83e-1 90/99 (90.91%) ITGAM;CD3G;CD33;...
Aldosterone synthesis and secretion -1.28 5.72e-1 85/98 (86.73%) CREB5;PRKACA;POMC;...
Oxidative phosphorylation -1.30 5.17e-1 93/133 (69.92%) ATP6V0E1;ATP5MC3;ATP5PF;...
Tryptophan metabolism -1.31 5.32e-1 35/42 (83.33%) ALDH8A1;TDO2;CYP1B1;...
Tyrosine metabolism -1.32 5.32e-1 30/36 (83.33%) TYR;HGD;ADH1B;...
Huntington disease -1.32 5.39e-1 233/306 (76.14%) GRIN2B;ATP5MC3;PLCB1;...
Taste transduction -1.33 5.34e-1 61/86 (70.93%) HTR1D;TAS2R1;CACNA1C;...
Prion disease -1.33 5.59e-1 209/273 (76.56%) GRIN2D;PSMD6;CYC1;...
Cortisol synthesis and secretion -1.35 5.20e-1 58/65 (89.23%) CREB5;PRKACA;POMC;...
Cytokine-cytokine receptor interaction -1.35 5.49e-1 246/295 (83.39%) IL36G;CSH1;NGF;...
RNA polymerase -1.36 5.76e-1 23/31 (74.19%) POLR2L;POLR3F;POLR3C;...
Non-alcoholic fatty liver disease -1.44 4.51e-1 126/155 (81.29%) CYC1;BAX;CDC42;...
Neuroactive ligand-receptor interaction -1.47 3.80e-1 294/341 (86.22%) BRS3;GLRA1;SSTR3;...
Ubiquinone and other terpenoid-quinone biosynthesis -1.53 2.73e-1 9/11 (81.82%) HPD;COQ2;GGCX;...
Adrenergic signaling in cardiomyocytes -1.61 1.71e-1 130/150 (86.67%) CACNG2;CACNA2D1;PPP1R1A;...
Hypertrophic cardiomyopathy -1.64 1.19e-1 81/90 (90%) ITGB8;CACNB4;ITGB1;...
Ribosome -1.65 1.37e-1 113/158 (71.52%) MRPL24;RPL18;RPL22;...
Dilated cardiomyopathy -1.66 1.41e-1 86/96 (89.58%) CACNG1;SLC8A2;MYL3;...
Cardiac muscle contraction -1.72 1.25e-1 64/87 (73.56%) TRDN;CACNG1;SLC8A2;...
Steroid hormone biosynthesis -1.76 1.44e-1 43/61 (70.49%) UGT2A3;AKR1D1;CYP1A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H