Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM37KVY)

Drug Name
HY-12638 Drug Info
Synonyms
Anthiphen; Dichlorophen; Antifen; Antiphen; Cordocel; Dicestal; Dichloorfeen; Dichlorofen; Dichlorophen B; Dichlorophene 10; Dichlorphen; Didroxan; Didroxane; Difentan; Diphenthane 70; Embephen; Fungicide GM; Fungicide M; Gingivit; Halenol; Hyosan; Korium; Palacel; Panacide; Parabis; Plath-Lyse; Prevental; Preventol GD; Preventol GDC; Sandocide; Super mosstox; Taeniatol; Teniathane; Teniatol; Teniotol; Trivex; Vermithana; Wespuril; dichlorophene; 2,2'-Methylenebis(4-chlorophenol); 97-23-4; Bis(5-chloro-2-hydroxyphenyl)methane; DDDM; Gefir
Cross-matching ID
PubChem CID
3037
ChEBI ID
CHEMBL33845
CAS Number
CAS 97-23-4
INTEDE Drug ID
DR2278

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 2.13 0.00e+0 52/108 (48.15%) FBL;NHP2;HEATR1;...
Ribosome 2.02 0.00e+0 113/158 (71.52%) MRPL24;MRPL28;MRPS2;...
RNA transport 1.83 1.83e-2 128/186 (68.82%) EIF2S3;KPNB1;EIF3J;...
One carbon pool by folate 1.81 2.75e-2 15/20 (75%) ATIC;GART;SHMT2;...
African trypanosomiasis 1.77 3.48e-2 32/37 (86.49%) IL1B;IDO1;VCAM1;...
Collecting duct acid secretion -1.72 3.89e-2 22/27 (81.48%) ATP6V0C;ATP6V1A;ATP6V1B1;...
Citrate cycle (TCA cycle) -1.74 3.31e-2 30/30 (100%) PDHB;FH;SDHB;...
Aldosterone-regulated sodium reabsorption -1.75 2.97e-2 34/37 (91.89%) SCNN1A;PRKCB;PIK3R3;...
Terpenoid backbone biosynthesis -1.76 3.14e-2 18/22 (81.82%) PCYOX1;ICMT;IDI1;...
Vibrio cholerae infection -1.76 3.46e-2 44/50 (88%) KCNQ1;ATP6V0C;ATP6V1A;...
Protein digestion and absorption -1.79 2.68e-2 78/103 (75.73%) SLC36A1;COL6A2;COL2A1;...
Glutathione metabolism -1.80 2.88e-2 43/57 (75.44%) PGD;RRM1;GSTM1;...
Diabetic cardiomyopathy -1.80 3.00e-2 162/203 (79.8%) MAPK9;ATP5F1B;NDUFB5;...
Phagosome -1.81 3.49e-2 118/152 (77.63%) PIK3C3;CANX;ATP6V1D;...
Proximal tubule bicarbonate reclamation -1.82 3.98e-2 21/23 (91.3%) ATP1A2;ATP1B1;MDH1;...
Steroid biosynthesis -1.82 4.72e-2 19/20 (95%) LSS;DHCR24;LIPA;...
Lysosome -2.24 0.00e+0 115/128 (89.84%) CTSD;SLC17A5;CTSH;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H