Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM385D9)

Drug Name
Tomelukast Drug Info
Synonyms LY-171883
Cross-matching ID
PubChem CID
3969
ChEBI ID
CHEMBL162358
CAS Number
CAS 88107-10-2
TTD Drug ID
D0S8YL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
RNA degradation 2.01 0.00e+0 53/79 (67.09%) PFKL;TENT4A;EXOSC4;...
Prion disease 1.86 8.50e-3 209/273 (76.56%) HSPA8;PSMC3;NDUFA4;...
Protein digestion and absorption 1.82 2.55e-2 78/103 (75.73%) COL6A2;COL15A1;COL14A1;...
DNA replication 1.81 1.91e-2 34/36 (94.44%) MCM2;RPA3;POLE2;...
RNA transport 1.80 1.70e-2 128/186 (68.82%) EEF1A2;NUP85;NUP107;...
Fanconi anemia pathway 1.75 2.83e-2 36/54 (66.67%) FANCG;RPA3;FANCI;...
Fat digestion and absorption 1.73 3.88e-2 35/43 (81.4%) APOB;APOA1;FABP1;...
Glycine, serine and threonine metabolism 1.71 3.93e-2 31/40 (77.5%) GATM;CBS;DLD;...
Primary bile acid biosynthesis -1.75 4.75e-2 15/17 (88.24%) BAAT;CH25H;CYP7B1;...
Parathyroid hormone synthesis, secretion and action -1.76 4.79e-2 98/106 (92.45%) PDE4D;SP1;NR4A2;...
Pantothenate and CoA biosynthesis -1.83 3.42e-2 14/21 (66.67%) DPYD;BCAT1;ALDH2;...
Lysosome -1.84 3.80e-2 115/128 (89.84%) CTSL;SMPD1;PLA2G15;...
beta-Alanine metabolism -1.87 3.99e-2 25/30 (83.33%) ALDH9A1;EHHADH;HADHA;...
Phagosome -1.98 0.00e+0 118/152 (77.63%) CTSL;ATP6V1F;RAB5C;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.001uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.001uM - 1.11uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.001uM - 1.11uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.001uM - 1.11uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.001uM - 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.001uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.001uM - 1.11uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.001uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.001uM - 1.11uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.001uM - 1.11uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.001uM - 1.11uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.001uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.001uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.001uM - 0.22uM 24H