Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM38VYQ)

• Drug Name: Pentolinium Drug Info
• Synonyms: Pentolineum; Pentolonium; Pentolonum; 1,1'-pentane-1,5-diylbis(1-methylpyrrolidinium); 1-methyl-1-[5-(1-methylpyrrolidin-1-ium-1-yl)pentyl]pyrrolidin-1-ium
• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 5850
  ChEBI ID: CHEMBL347401
  CAS Number: CAS 144-44-5
  TTD Drug ID: D0IX1A

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Phagosome	-1.67	4.73e-2	118/152 (77.63%)	CD209;FCGR2A;OLR1;...
Inflammatory bowel disease	-1.68	4.64e-2	58/65 (89.23%)	RORA;MAF;TLR2;...
Neutrophil extracellular trap formation	-1.69	4.38e-2	101/189 (53.44%)	TLR7;PLCB2;VDAC2;...
Chagas disease	-1.71	3.64e-2	93/102 (91.18%)	KNG1;PIK3R3;PIK3R1;...
Leishmaniasis	-1.72	3.29e-2	67/77 (87.01%)	NCF2;FOS;PTPN6;...
Type I diabetes mellitus	-1.72	3.51e-2	38/43 (88.37%)	IL1B;FAS;IFNG;...
VEGF signaling pathway	-1.72	3.57e-2	50/59 (84.75%)	KDR;PPP3CC;PLCG2;...
Coronavirus disease	-1.76	2.53e-2	215/232 (92.67%)	PIK3R3;PIK3R1;IFIH1;...
Pertussis	-1.77	2.41e-2	64/76 (84.21%)	IRAK1;TNF;TLR4;...
Th1 and Th2 cell differentiation	-1.78	2.51e-2	80/92 (86.96%)	STAT6;PPP3CA;FOS;...
B cell receptor signaling pathway	-1.78	2.50e-2	71/81 (87.65%)	PPP3CC;LILRB1;SOS2;...
Insulin resistance	-1.83	1.75e-2	96/108 (88.89%)	PRKAB2;MLXIP;PTEN;...
Arginine biosynthesis	-1.84	1.97e-2	17/22 (77.27%)	GOT2;GLUL;GLS2;...
Ferroptosis	-1.86	2.07e-2	36/41 (87.8%)	TF;STEAP3;SLC39A14;...
Phenylalanine metabolism	-1.89	1.53e-2	14/17 (82.35%)	GLYAT;MAOA;PAH;...
Long-term depression	-1.89	1.84e-2	55/60 (91.67%)	PPP2CB;KRAS;GNAI1;...
Staphylococcus aureus infection	-1.98	1.32e-2	72/95 (75.79%)	KRT23;KRT18;HLA-DQB1;...
Autophagy	-2.02	1.32e-2	113/169 (66.86%)	PRKACB;PIK3R3;MAP2K1;...
Systemic lupus erythematosus	-2.04	1.97e-2	45/135 (33.33%)	C7;TNF;HLA-DQB1;...
Complement and coagulation cascades	-2.23	0.00e+0	76/85 (89.41%)	C3AR1;PROC;F9;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	24H	Hide ▲