Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3ADGP)

Drug Name
Rhucin Drug Info
Synonyms
sildenafil; 139755-83-2; VIAGRA; Sildenafil [INN:BAN]; UK-92480; UNII-3M7OB98Y7H; UK-92,480-10; C22H30N6O4S; HSDB 7305; CHEMBL192; UK 92480-10; CHEBI:9139; 3M7OB98Y7H; 1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine; BNRNXUUZRGQAQC-UHFFFAOYSA-N; 5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one; Sildenafil
Cross-matching ID
PubChem CID
135398744
ChEBI ID
CHEMBL9139
CAS Number
CAS 139755-83-2
TTD Drug ID
D0Z7ZM
VARIDT Drug ID
DR00565
ACDINA Drug ID
D00622

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.55 0.00e+0 34/36 (94.44%) PCNA;MCM6;POLE2;...
Mismatch repair 2.08 0.00e+0 22/23 (95.65%) PCNA;RFC3;MSH2;...
Proteasome 2.08 0.00e+0 44/46 (95.65%) PSMC6;PSMA2;PSMD2;...
Base excision repair 2.05 1.44e-3 29/33 (87.88%) PCNA;POLE2;FEN1;...
Cell cycle 1.96 1.16e-3 110/124 (88.71%) PCNA;PLK1;MCM6;...
Spliceosome 1.96 9.63e-4 101/150 (67.33%) HSPA8;PUF60;HSPA2;...
Parkinson disease 1.95 8.26e-4 176/249 (70.68%) GNAS;CALML5;UCHL1;...
Fanconi anemia pathway 1.91 2.17e-3 36/54 (66.67%) REV3L;FANCL;RMI1;...
Mannose type O-glycan biosynthesis 1.72 1.35e-2 14/23 (60.87%) B4GAT1;CHST10;LARGE1;...
Aminoacyl-tRNA biosynthesis 1.70 1.50e-2 15/66 (22.73%) NARS2;SARS2;FARSA;...
Spinocerebellar ataxia 1.61 4.10e-2 128/143 (89.51%) PSMC6;PSMA2;VDAC3;...
Amyotrophic lateral sclerosis 1.58 4.96e-2 267/364 (73.35%) PFN2;PSMC6;TNFRSF1A;...
Oocyte meiosis 1.58 4.80e-2 90/129 (69.77%) CALML5;PLK1;CCNB1;...
Autophagy -1.64 3.55e-2 113/169 (66.86%) ULK1;SH3GLB1;PRKACB;...
Complement and coagulation cascades -1.64 3.57e-2 76/85 (89.41%) SERPINA5;ITGAX;CR1;...
Tuberculosis -1.65 3.64e-2 159/180 (88.33%) CORO1A;HLA-DQB1;CYCS;...
African trypanosomiasis -1.65 3.63e-2 32/37 (86.49%) IL1B;APOL1;FAS;...
Systemic lupus erythematosus -1.67 3.64e-2 45/135 (33.33%) C1QB;HLA-DPB1;HLA-DMB;...
Bladder cancer -1.68 3.68e-2 40/41 (97.56%) NRAS;E2F3;BRAF;...
Staphylococcus aureus infection -1.72 2.47e-2 72/95 (75.79%) C1QB;HLA-DPB1;HLA-DMB;...
Mitophagy -1.73 2.36e-2 56/68 (82.35%) MITF;NRAS;GABARAPL1;...
Endometrial cancer -1.73 2.46e-2 56/58 (96.55%) TCF7;PDPK1;TCF7L2;...
TNF signaling pathway -1.76 1.86e-2 103/112 (91.96%) BAG4;CREB3L1;NFKB1;...
Glycine, serine and threonine metabolism -1.77 1.89e-2 31/40 (77.5%) GCAT;SDS;AOC3;...
beta-Alanine metabolism -1.78 1.86e-2 25/30 (83.33%) AOC3;DPYS;HADHA;...
B cell receptor signaling pathway -1.78 1.96e-2 71/81 (87.65%) AKT3;NRAS;RAC1;...
Primary immunodeficiency -1.79 2.00e-2 33/38 (86.84%) ICOS;CD3E;CIITA;...
Intestinal immune network for IgA production -1.79 2.13e-2 38/48 (79.17%) HLA-DPB1;HLA-DMB;ICOS;...
Other glycan degradation -1.79 2.02e-2 13/18 (72.22%) HEXA;ENGASE;MAN2B1;...
Retinol metabolism -1.81 1.44e-2 41/68 (60.29%) UGT2B17;RETSAT;UGT2B15;...
Phagosome -1.81 1.55e-2 118/152 (77.63%) CORO1A;HLA-DQB1;ATP6V0E2;...
Ferroptosis -1.84 1.15e-2 36/41 (87.8%) SLC39A8;FTH1;ACSL5;...
Butanoate metabolism -1.86 5.73e-3 23/28 (82.14%) HADHA;ABAT;OXCT1;...
PPAR signaling pathway -1.90 2.52e-3 66/74 (89.19%) OLR1;ACSL4;APOC3;...
Steroid biosynthesis -1.91 2.80e-3 19/20 (95%) DHCR7;TM7SF2;LIPA;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.92 1.57e-3 79/89 (88.76%) CD247;AKT3;NRAS;...
Leishmaniasis -1.96 0.00e+0 67/77 (87.01%) NFKB1;PTPN6;IL1B;...
Th1 and Th2 cell differentiation -1.97 0.00e+0 80/92 (86.96%) NFKBIE;HLA-DQB1;STAT4;...
Osteoclast differentiation -1.98 0.00e+0 117/127 (92.13%) TNFRSF11A;CALCR;JAK1;...
Hematopoietic cell lineage -2.08 0.00e+0 90/99 (90.91%) DNTT;FCER2;HLA-DQB1;...
Lysosome -2.13 0.00e+0 115/128 (89.84%) CTSO;MANBA;ATP6V0A2;...
NF-kappa B signaling pathway -2.19 0.00e+0 90/104 (86.54%) CCL19;TNFRSF11A;PLAU;...
Rheumatoid arthritis -2.26 0.00e+0 78/93 (83.87%) CTLA4;TNFRSF11A;TEK;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 150uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 150uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 150uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 150uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 150uM 6H
MDST8 CVCL_1400 Homo sapiens 150uM 6H
NCI-H508 CVCL_1561 Homo sapiens 150uM 6H
SNU-1040 CVCL_5001 Homo sapiens 150uM 6H
SNU-C4 CVCL_5008 Homo sapiens 150uM 6H
SNU-C5 CVCL_5009 Homo sapiens 150uM 6H
SW480 CVCL_0546 Homo sapiens 150uM 6H
SW620 CVCL_0547 Homo sapiens 150uM 6H
SW948 CVCL_0550 Homo sapiens 150uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 150uM 6H
HT115 CVCL_1294 Homo sapiens 150uM 6H
RKO CVCL_0504 Homo sapiens 150uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 150uM 6H
SNG-M CVCL_1707 Homo sapiens 150uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 150uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 150uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 150uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 6.66uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 150uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 150uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 150uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 150uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 150uM 6H
T3M-10 CVCL_1729 Homo sapiens 150uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 150uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 150uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 150uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 150uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 150uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 150uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 150uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 150uM 6H
OV7 CVCL_1623 Homo sapiens 150uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 150uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 150uM 6H
RMUG-S CVCL_1666 Homo sapiens 150uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 150uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 150uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 150uM 6H
PL-21 CVCL_2161 Homo sapiens 150uM 6H
SKM-1 CVCL_0010 Homo sapiens 150uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 150uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 150uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM - 150uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 150uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 150uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 150uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 150uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H