Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3AGUQ)

Drug Name
EMD-386088 Drug Info
Synonyms compound 18 [PMID 16055331]; EMD 386088; EMD386088
Cross-matching ID
PubChem CID
10131112
ChEBI ID
CHEMBL364005
CAS Number
CAS 54635-62-0
TTD Drug ID
D0G7QT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ferroptosis 2.16 0.00e+0 36/41 (87.8%) FTH1;STEAP3;CP;...
Citrate cycle (TCA cycle) 2.00 0.00e+0 30/30 (100%) PCK2;IDH1;CS;...
PPAR signaling pathway 1.98 0.00e+0 66/74 (89.19%) SCD;PCK2;FABP7;...
Steroid biosynthesis 1.88 7.32e-3 19/20 (95%) MSMO1;SQLE;FDFT1;...
Glyoxylate and dicarboxylate metabolism 1.85 1.17e-2 23/30 (76.67%) ACAT2;GLUL;CS;...
Terpenoid backbone biosynthesis 1.75 4.23e-2 18/22 (81.82%) ACAT2;HMGCS1;HMGCR;...
Th1 and Th2 cell differentiation -1.74 1.95e-2 80/92 (86.96%) IL12A;STAT1;PRKCQ;...
Allograft rejection -1.75 2.05e-2 32/38 (84.21%) HLA-DRA;HLA-DQB1;HLA-DPA1;...
Graft-versus-host disease -1.78 1.70e-2 32/42 (76.19%) IL1B;HLA-DRA;HLA-DQB1;...
C-type lectin receptor signaling pathway -1.78 1.79e-2 93/104 (89.42%) ITPR2;SRC;RELA;...
Staphylococcus aureus infection -1.78 2.05e-2 72/95 (75.79%) PLG;FCGR2B;FCGR2A;...
Th17 cell differentiation -1.79 2.22e-2 95/107 (88.79%) CD3E;NFKBIA;HLA-DOA;...
Colorectal cancer -1.81 2.05e-2 84/86 (97.67%) SMAD4;LEF1;RALA;...
Inflammatory bowel disease -1.85 1.79e-2 58/65 (89.23%) RELA;SMAD3;STAT3;...
Hematopoietic cell lineage -1.88 1.70e-2 90/99 (90.91%) CD9;CD3E;GP9;...
Systemic lupus erythematosus -1.97 1.53e-2 45/135 (33.33%) CD80;SNRPD1;C1R;...
Asthma -2.05 1.02e-2 25/31 (80.65%) IL4;EPX;HLA-DOA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H