Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3BI7R)

Drug Name
GSK-2334470 Drug Info
Synonyms PDK1 inhibitors, GlaxoSmithKline
Cross-matching ID
PubChem CID
46215815
ChEBI ID
CHEMBL1765740
CAS Number
CAS 1227911-45-6
TTD Drug ID
D0EU1R

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Notch signaling pathway 1.91 1.68e-2 49/59 (83.05%) RFNG;HES1;CTBP2;...
Focal adhesion 1.89 1.68e-2 180/201 (89.55%) IGF1R;THBS1;PDGFRA;...
ECM-receptor interaction 1.80 4.21e-2 80/88 (90.91%) THBS1;ITGB5;COL4A2;...
Axon guidance 1.76 4.63e-2 151/182 (82.97%) RASA1;SEMA5A;PLXNB2;...
Hedgehog signaling pathway 1.75 4.21e-2 43/56 (76.79%) SMURF2;GAS1;GPR161;...
Alzheimer disease -1.61 3.76e-2 279/369 (75.61%) TUBB;COX7B;ATP2A3;...
Pathways of neurodegeneration -1.62 3.54e-2 354/475 (74.53%) TNFRSF1B;COX7A2;TUBB;...
Synaptic vesicle cycle -1.62 3.63e-2 63/78 (80.77%) CLTB;AP2M1;ATP6V1G1;...
Fat digestion and absorption -1.62 3.76e-2 35/43 (81.4%) PLA2G3;FABP1;ACAT2;...
Terpenoid backbone biosynthesis -1.64 3.47e-2 18/22 (81.82%) FDPS;PDSS1;HMGCR;...
Alanine, aspartate and glutamate metabolism -1.67 2.69e-2 27/37 (72.97%) ASRGL1;PPAT;ASPA;...
Antigen processing and presentation -1.67 2.80e-2 60/78 (76.92%) PSME2;HLA-DPA1;PDIA3;...
Protein export -1.69 2.43e-2 17/23 (73.91%) SEC61G;SEC61A2;SEC63;...
Biosynthesis of unsaturated fatty acids -1.72 1.92e-2 21/27 (77.78%) ACOX1;FADS2;SCP2;...
IL-17 signaling pathway -1.74 1.79e-2 84/94 (89.36%) MAPK9;ELAVL1;JUN;...
Steroid biosynthesis -1.74 1.77e-2 19/20 (95%) NSDHL;SC5D;CYP27B1;...
Huntington disease -1.77 1.44e-2 233/306 (76.14%) TUBB;COX7B;KIF5A;...
Citrate cycle (TCA cycle) -1.77 1.46e-2 30/30 (100%) FH;SDHC;SDHD;...
Porphyrin and chlorophyll metabolism -1.77 1.54e-2 23/43 (53.49%) BLVRA;FECH;UGT2B17;...
Spinocerebellar ataxia -1.88 4.28e-3 128/143 (89.51%) SLC25A5;PSMA6;PRKCB;...
Amyotrophic lateral sclerosis -1.91 3.80e-3 267/364 (73.35%) TNFRSF1B;COX7A2;TUBB;...
Ribosome biogenesis in eukaryotes -1.92 4.07e-3 52/108 (48.15%) RRP7A;EFL1;DROSHA;...
Rheumatoid arthritis -1.95 2.63e-3 78/93 (83.87%) CSF1;ATP6AP1;ATP6V1G1;...
Legionellosis -1.98 1.90e-3 51/57 (89.47%) SAR1A;IL6;IL18;...
Folate biosynthesis -2.00 2.07e-3 23/26 (88.46%) GGH;PTS;QDPR;...
Oxidative phosphorylation -2.02 1.14e-3 93/133 (69.92%) NDUFA3;NDUFA5;NDUFS4;...
Amino sugar and nucleotide sugar metabolism -2.03 1.27e-3 38/48 (79.17%) CYB5R2;HKDC1;NAGK;...
Fructose and mannose metabolism -2.05 1.43e-3 30/33 (90.91%) TPI1;HK3;ENOSF1;...
Arginine and proline metabolism -2.05 1.63e-3 39/50 (78%) PYCR1;GATM;ARG2;...
Collecting duct acid secretion -2.05 1.90e-3 22/27 (81.48%) ATP6V1G1;ATP6V1A;ATP6V0E1;...
Prion disease -2.08 2.28e-3 209/273 (76.56%) COX7A2;TUBB;COX7B;...
Parkinson disease -2.09 2.85e-3 176/249 (70.68%) COX7A2;TUBB;COX7B;...
Protein processing in endoplasmic reticulum -2.23 0.00e+0 127/171 (74.27%) MAPK9;SEC24A;RAD23B;...
Ferroptosis -2.23 0.00e+0 36/41 (87.8%) VDAC3;TF;ATG5;...
Proteasome -2.43 0.00e+0 44/46 (95.65%) IFNG;PSMB3;PSMF1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 0.12uM 6H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 0.12uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 0.12uM 6H
MDST8 CVCL_1400 Homo sapiens 0.12uM 6H
NCI-H508 CVCL_1561 Homo sapiens 0.12uM 6H
SNU-1040 CVCL_5001 Homo sapiens 0.12uM 6H
SNU-C4 CVCL_5008 Homo sapiens 0.12uM 6H
SNU-C5 CVCL_5009 Homo sapiens 0.12uM 6H
SW480 CVCL_0546 Homo sapiens 0.12uM 6H
SW620 CVCL_0547 Homo sapiens 0.12uM 6H
SW948 CVCL_0550 Homo sapiens 0.12uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 0.12uM 6H
HT115 CVCL_1294 Homo sapiens 0.12uM 6H
RKO CVCL_0504 Homo sapiens 0.12uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM 6H
SNG-M CVCL_1707 Homo sapiens 0.12uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 0.12uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
DV-90 CVCL_1184 Homo sapiens 0.12uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 0.12uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 0.12uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 0.12uM 6H
T3M-10 CVCL_1729 Homo sapiens 0.12uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 0.12uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 0.12uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 0.12uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 0.12uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 0.12uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 0.12uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 0.12uM 6H
OV7 CVCL_1623 Homo sapiens 0.12uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 0.12uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 0.12uM 6H
RMUG-S CVCL_1666 Homo sapiens 0.12uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 0.12uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 0.12uM 6H
PL-21 CVCL_2161 Homo sapiens 0.12uM 6H
SKM-1 CVCL_0010 Homo sapiens 0.12uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 0.12uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.12uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 0.12uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 0.12uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H