Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3BN4W)

• Drug Name: CFI-400945 Drug Info
• Synonyms: CFI 400945; CFI400945
• Cross-matching ID:
  PubChem CID: 58486178
  ChEBI ID: CHEMBL3408947
  CAS Number: CAS 1338806-73-7
  TTD Drug ID: D0X2XZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Primary immunodeficiency	2.22	0.00e+0	33/38 (86.84%)	CD3D;CD79A;IL7R;...
p53 signaling pathway	2.07	0.00e+0	63/73 (86.3%)	CDKN1A;CCNB1;SFN;...
Cytokine-cytokine receptor interaction	1.93	7.30e-3	246/295 (83.39%)	CXCL13;CXCL9;LTB;...
Bacterial invasion of epithelial cells	1.91	8.22e-3	59/77 (76.62%)	MET;FN1;ARPC5;...
Pyrimidine metabolism	1.88	1.10e-2	40/56 (71.43%)	TYMS;UPP1;ENTPD1;...
Autoimmune thyroid disease	1.75	4.93e-2	46/53 (86.79%)	TG;TSHR;CD40;...
Ovarian steroidogenesis	-1.92	3.54e-2	41/51 (80.39%)	CYP2J2;CYP17A1;INS;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲