Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3BS97)

Drug Name
Macrolides Drug Info
Synonyms
Tylosin; tylosin tartrate; Tilosina; Tylosinum; UNII-YEF4JXN031; Tylosine; Tylocine; Tylan; Tylosin A; 1401-69-0; YEF4JXN031; Fradizine; CHEBI:17658; Vubityl 200; Tylosinum [INN-Latin]; Tylosine [INN-French]; Tilosina [INN-Spanish]; HSDB 7022; EINECS 215-754-8; AI3-29799; SR-05000002057; Tylosin [USP:INN:BAN]; Tylan (TN); Tylosin (USP/INN); AC1NQX0W
Cross-matching ID
PubChem CID
5280440
ChEBI ID
CHEMBL17658
CAS Number
CAS 1401-69-0
TTD Drug ID
D0Q6OS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Primary immunodeficiency -1.86 2.02e-2 33/38 (86.84%) ADA;CD8B;CD3E;...
Primary bile acid biosynthesis -1.88 2.70e-2 15/17 (88.24%) CYP39A1;CYP7A1;CYP27A1;...
Renin-angiotensin system -1.90 2.89e-2 20/23 (86.96%) AGT;ENPEP;KLK2;...
Hematopoietic cell lineage -1.98 1.16e-2 90/99 (90.91%) HLA-DPB1;GYPA;IL6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 4uM 72H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H